The rate of metabolism as a factor determining longevity of the Saccharomyces cerevisiae yeast

Age
Mateusz MolonRenata Zadrag-Tecza

Abstract

Despite many controversies, the yeast Saccharomyces cerevisiae continues to be used as a model organism for the study of aging. Numerous theories and hypotheses have been created for several decades, yet basic mechanisms of aging have remained unclear. Therefore, the principal aim of this work is to propose a possible mechanism leading to increased longevity in yeast. In this paper, we suggest for the first time that there is a link between decreased metabolic activity, fertility and longevity expressed as time of life in yeast. Determination of reproductive potential and total lifespan with the use of fob1Δ and sfp1Δ mutants allows us to compare the "longevity" presented as the number of produced daughters with the longevity expressed as the time of life. The results of analyses presented in this paper suggest the need for a change in the definition of longevity of yeast by taking into consideration the time parameter. The mutants that have been described as "long-lived" in the literature, such as the fob1Δ mutant, have an increased reproductive potential but live no longer than their standard counterparts. On the other hand, the sfp1Δ mutant and the wild-type strain produce a similar number of daughter cells, but the former l...Continue Reading

References

Sep 1, 1976·Mechanisms of Ageing and Development·J MiquelH Atlan
Jul 31, 1985·Biochemical and Biophysical Research Communications·T BilińskiJ Litwińska
Jan 1, 1980·Mechanisms of Ageing and Development·I MüllerM Flömer
Jan 15, 1998·Cell·D A Sinclair, L Guarente
Nov 21, 1998·Free Radical Biology & Medicine·L BenovI Fridovich
Jan 19, 1999·Annual Review of Microbiology·D SinclairL Guarente
Nov 5, 1999·Trends in Biochemical Sciences·J R Warner
Nov 23, 2000·Mechanisms of Ageing and Development·H Gershon, D Gershon
Mar 1, 2003·Science·Hugo AguilaniuThomas Nyström
Jun 20, 1959·Nature·R K MORTIMER, J R JOHNSTON
Oct 14, 2003·Eukaryotic Cell·Ian FingermanAndrew K Vershon
Jan 16, 2004·Genes & Development·Su-Ju LinLeonard Guarente
Oct 19, 2004·Genes & Development·Dipayan Rudra, Jonathan R Warner
Dec 22, 2004·Mechanisms of Ageing and Development·Matt Kaeberlein, Brian K Kennedy
Dec 31, 2004·Proceedings of the National Academy of Sciences of the United States of America·Nadège MinoisJames W Vaupel
Feb 22, 2005·Mechanisms of Ageing and Development·Matt KaeberleinBrian K Kennedy
Oct 3, 2006·Cell Metabolism·Dietmar E MartinMichael N Hall
Jan 21, 2011·Cell Cycle·Jingye YangBrandt L Schneider
Nov 19, 2011·FEMS Yeast Research·Tomasz BilińskiGrzegorz Bartosz
Mar 7, 2012·FEMS Yeast Research·Austen R D GanleyTakehiko Kobayashi
Aug 23, 2012·FEMS Yeast Research·Tomasz Bilinski
Sep 7, 2012·Cell Cycle·Michael Polymenis, Brian K Kennedy
Oct 31, 2012·FEMS Yeast Research·Jill WrightBrandt L Schneider
Mar 8, 2013·Molecular Biology of the Cell·Rebecca R ThorburnAngelika Amon
Aug 27, 2014·FEMS Yeast Research·Magdalena Kwolek-Mirek, Renata Zadrag-Tecza
Mar 31, 2015·Biochemical and Biophysical Research Communications·Mateusz MolonTomasz Bilinski
Oct 21, 2015·Biogerontology·Mateusz Molon, Renata Zadrag-Tecza

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Citations

Jun 20, 2017·PLoS Computational Biology·David L Gibbs, Ilya Shmulevich
Jun 14, 2017·Molecular and Cellular Biology·Leszek WawiórkaMarek Tchórzewski
Apr 11, 2018·Canadian Journal on Aging = La Revue Canadienne Du Vieillissement·Ann M TooheyMelanie J Rock
Jul 25, 2019·Cells·Lidia BorkiewiczMarek Tchórzewski
Dec 18, 2020·International Journal of Molecular Sciences·Jadwiga CzachorMateusz Mołoń

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Methods Mentioned

BETA
Assay
PCR
density gradient fractionation
fluorescence microscopy

Software Mentioned

cellSens Standard
StatSoft
TAM Assistant
cellSense Dimension

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