The rate of the thrombin/antithrombin III reaction is determined with their molar ratio rather than their absolute concentrations

Thrombosis Research
G Oshima, K Nagasawa


A pico-molar concentration of thrombin was significantly inactivated by antithrombin III (AT III). The pseudo-first order rate constant, k'app, and the second order rate constant, k", were inversely proportional to the concentration of thrombin. The k'app and k" values increased and decreased, respectively, with increase in the concentration of AT III. All of these results indicated that the rate of the thrombin/AT III reaction was determined with the molar ratio of the two rather than their absolute concentrations.


Sep 1, 1978·The Biochemical Journal·R Machovich, P Arányi
Jun 1, 1976·Thrombosis Research·W WasiewskiJ W Fenton
Oct 20, 1975·Biochimica Et Biophysica Acta·W G Owen
Sep 16, 1975·Biochemical and Biophysical Research Communications·R L LundbladK G Mann
Nov 1, 1986·Thrombosis Research·G Oshima

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