PMID: 9635110Jun 23, 1998Paper

The ratio of erythrocyte zinc-protoporphyrin to protoporphyrin IX in disease and its significance in the mechanism of lead toxicity on haem synthesis

Annals of Clinical Biochemistry
J C NelsonJ H Barth

Abstract

Protoporphyrin and zinc-protoporphyrin were measured in the erythrocytes of normal subjects, workers exposed to lead and patients with iron deficiency and erythropoietic protoporphyria (EPP). Results showed significantly higher levels of zinc-protoporphyrin in the lead-exposed workers (P < 0.0001), patients with iron deficiency (P < 0.0001) and EPP patients (P < 0.001) compared with normal subjects. The lead-exposed workers showed the highest levels of zinc-protoporphyrin, which were significantly greater than both the iron-deficient and EPP patients (P < 0.0001). They also showed a higher ratio of zinc-protoporphyrin to free protoporphyrin compared with normal subjects (P < 0.0001) but no significant difference in this ratio was found when compared with iron-deficient patients (P = 0.1). These results are discussed in light of the controversy concerning the mechanism of formation of zinc-protoporphyrin in lead exposure.

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Citations

Nov 22, 2015·The Journal of Pharmacology and Experimental Therapeutics·Madhav SacharXiaochao Ma
Oct 10, 2018·Postgraduate Medicine·Loukas KakoullisGeorge Panos
Nov 6, 2020·Cell Metabolism·Douglas E BiancurAlec C Kimmelman

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