The ratio of N-acetyl aspartate to glutamate correlates with disease duration of amyotrophic lateral sclerosis

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Wataru SakoRyuji Kaji

Abstract

Glutamate (Glu)-induced excitotoxicity has been implicated in the neuronal loss of amyotrophic lateral sclerosis. To test the hypothesis that Glu in the primary motor cortex contributes to disease severity and/or duration, the Glu level was investigated using MR spectroscopy. Seventeen patients with amyotrophic lateral sclerosis were diagnosed according to the El Escorial criteria for suspected, possible, probable or definite amyotrophic lateral sclerosis, and enrolled in this cross-sectional study. We measured metabolite concentrations, including N-acetyl aspartate (NAA), creatine, choline, inositol, Glu and glutamine, and performed partial correlation between each metabolite concentration or NAA/Glu ratio and disease severity or duration using age as a covariate. Considering our hypothesis that Glu is associated with neuronal cell death in amyotrophic lateral sclerosis, we investigated the ratio of NAA to Glu, and found a significant correlation between NAA/Glu and disease duration (r=-0.574, p=0.02). The "suspected" amyotrophic lateral sclerosis patients showed the same tendency as possible, probable and definite amyotrophic lateral sclerosis patients in regard to correlation of NAA/Glu ratio with disease duration. The other...Continue Reading

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Citations

Feb 13, 2018·Molecular Neurobiology·Blandine Madji HounoumSylvie Mavel
Oct 2, 2019·Neurochemical Research·Tao KeMichael Aschner
Aug 18, 2020·Journal of Neural Transmission·Ze-Xu WeiYong Cheng
Apr 20, 2019·Frontiers in Neurology·Nick S VerberPamela J Shaw
Feb 18, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Wataru SakoRyuji Kaji

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