The ratio of the absolute lymphocyte count to the absolute monocyte count is associated with prognosis in Hodgkin's lymphoma: correlation with tumor-associated macrophages.

The Oncologist
Young Wha KohJooryung Huh

Abstract

Although most patients with classical Hodgkin's lymphoma (cHL) have a long survival duration, the current risk stratification is imperfect. A recent study suggested a prognostic role for the peripheral blood absolute lymphocyte count/absolute monocyte count (ALC/AMC) ratio at diagnosis in cHL. It is intriguing to investigate the significance of the ALC/AMC ratio in relation to tumor-associated macrophages (TAMs), yet another prognostic factor for cHL. We examined the prognostic impact of the ALC, AMC, and ALC/AMC ratio in 312 cHL patients (median age, 37 years) using receiver operating characteristic curve analysis for optimal cutoff values, and compared these with TAM content. The median follow-up was 65 months (range, 0.1-245 months). On univariate analysis, a low ALC/AMC ratio (<2.9) was correlated with a poorer overall survival (OS) outcome. A subgroup analysis of patients with limited-stage disease showed that the ALC/AMC ratio was significantly correlated with the OS time. Multivariate analysis showed the ALC/AMC ratio to be an independent prognostic factor for OS outcome. A Spearman correlation test of TAM content showed a negative correlation with the ALC/AMC ratio and a positive correlation with the peripheral blood ma...Continue Reading

References

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Citations

Apr 6, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Young Wha KohJooryung Huh
Jul 22, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Shogo KumagaiCheng-Long Huang
Aug 2, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Gui-Nan LinXiao-Qin Chen
Apr 11, 2015·Leukemia & Lymphoma·Ruben Fernandez-AlvarezJuan M Sancho
Nov 22, 2015·Journal of the Chinese Medical Association : JCMA·Isil GuzelFikri Ak
May 28, 2013·Leukemia Research·Carla CasuloCraig H Moskowitz
Dec 3, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Piero FarruggiaUNKNOWN AIEOP (Italian Association of Pediatric Hematology and Oncology) and Hodgkin Lymphoma working group
Jul 3, 2013·British Journal of Haematology·Kathrin Aprile von HohenstaufenEmanuele Zucca
Apr 30, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Se-Il GoGyeong-Won Lee
Oct 5, 2016·Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology·Tolga Han EfeEkrem Yeter
Jan 14, 2016·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Sani Namik MuratFatih Oksuz
Mar 13, 2014·American Journal of Clinical Pathology·Young Wha KohJooryung Huh

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