PMID: 889670Aug 1, 1977

The rational use of i.v. hydrochloric acid in the treatment of metabolic alkalosis

British Journal of Anaesthesia
L I Worthley


A method for the assessment and management of factors both causing and maintaining a primary metabolic alkalosis is presented. During a 2-year period 65 patients with metabolic alkalosis were treated with saline and potassium chloride infusions. In four patients the alkalosis was refractory and required additional therapy. An infusion of hydrochloric acid 0.12-0.24 mol/litre through a central venous line corrected the alkalosis without causing haemolysis or tissue necrosis. The maximum rate of infusion suggested is 0.2 mmol H+-kg body wt-1-h-1.


Mar 12, 2010·The Journal of Trauma·Simru TugrulNahit Cakar
Nov 26, 1977·British Medical Journal·P J Howorth
Feb 1, 1985·Kidney International·P A Gabow
Nov 24, 1999·Critical Reviews in Clinical Laboratory Sciences·N R Webster, V Kulkarni
Jan 24, 2018·The Annals of Pharmacotherapy·Jason D GuffeyDavid C Kaufman
Nov 1, 1982·Anaesthesia and Intensive Care·L I Worthley

Related Concepts

Metabolic Alkalosis
Postoperative Complications
Potassium Chloride
Hemolysis (Biological Funtion)
Parenteral Infusion
Hydrogen Chloride

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