The rationale, efficacy and safety evidence for tegaserod in the treatment of irritable bowel syndrome

Expert Opinion on Drug Safety
John McLaughlin, Lesley A Houghton

Abstract

A growing body of evidence implicates abnormal serotonergic regulation of gastrointestinal function in the pathogenesis of the irritable bowel syndrome (IBS). Drugs targeting this system are therefore attractive concepts. The partial 5-HT4 receptor agonist tegaserod might be predicted to have positive therapeutic effects on a constipated and uncomfortable gut. However, IBS runs a chronic, benign course and carries no associated mortality, so it is imperative that the safety profile of new pharmacological agents made available to physicians is exemplary. The authors review the evidence for 5-HT in the aetiology of IBS and its symptoms, and the data available concerning the partial 5-HT4 receptor agonist tegaserod, in terms of rationale, efficacy and safety.

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Citations

May 10, 2007·Gut·R SpillerUNKNOWN Clinical Services Committee of The British Society of Gastroenterology
Jan 27, 2007·Pharmacotherapy·Pramodini B Kale-Pradhan, Sheila M Wilhelm
Nov 17, 2007·Current Opinion in Pharmacology·Sylvie Bradesi, Emeran A Mayer
May 19, 2007·Digestion·Manfred G IsmairStephan R Vavricka
Sep 17, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Rachel M Gwynne, Joel C Bornstein

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