The Rationale for Monitoring Cognitive Function in Multiple Sclerosis: Practical Issues for Clinicians

The Open Neurology Journal
Christos BakirtzisNikolaos Grigoriadis

Abstract

About half of patients with multiple sclerosis exhibit cognitive impairment which negatively affects their quality of life. The assessment of cognitive function in routine clinical practice is still undervalued, although various tools have been proposed for this reason. In this article, we describe the potential benefits of implementing cognitive assessment tools in routine follow -ups of MS patients. Early detection of changes in cognitive performance may provide evidence of disease activity, could unmask depression or medication side-effects and provide suitable candidates for cognitive rehabilitation. Since apathy and cognitive deficiencies are common presenting symptoms in Progressive Multifocal Leukoencephalopathy, we discuss the utility of frequent monitoring of mental status in multiple sclerosis patients at increased risk. In addition, we propose a relevant algorithm aiming to incorporate a systematic evaluation of cognitive function in every day clinical practice in multiple sclerosis.

References

Apr 1, 1977·Perceptual and Motor Skills·D M Gronwall
Oct 1, 1986·Journal of Clinical and Experimental Neuropsychology·S M Rao
Jun 1, 1983·Acta Psychiatrica Scandinavica·A S Zigmond, R P Snaith
May 12, 1998·Journal of Neurology, Neurosurgery, and Psychiatry·J FoongM A Ron
Dec 9, 1998·Journal of Clinical and Experimental Neuropsychology·J DeLucaR A Engel
Apr 20, 2001·Journal of the International Neuropsychological Society : JINS·J D Fisk, C J Archibald
Jun 11, 2002·International Journal of Technology Assessment in Health Care
Mar 6, 2003·Multiple Sclerosis : Clinical and Laboratory Research·R H B BenedictL Jacobs
Sep 21, 2004·The Journal of Neuropsychiatry and Clinical Neurosciences·Inna FishmanBianca Weinstock-Guttman
Nov 12, 2005·Annals of Neurology·Chris H PolmanJerry S Wolinsky
Apr 13, 2006·Journal of Neurology·Maria Pia AmatoMaria Trojano
Apr 29, 2006·Journal of the Neurological Sciences·Anthony Feinstein
Sep 20, 2006·Journal of the International Neuropsychological Society : JINS·Ralph H B BenedictBianca Weinstock-Guttman
Apr 21, 2007·Journal of the International Neuropsychological Society : JINS·Brett A ParmenterDavid W Shucard
May 16, 2007·Journal of Neurology·Pasquale Calabrese, Iris Katharina Penner
Sep 19, 2007·Neurology·M K HoutchensR Bakshi
Sep 21, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A AchironE S Simon
Oct 28, 2008·Brain : a Journal of Neurology·R A DineenD P Auer
Jul 4, 2009·Journal of the International Neuropsychological Society : JINS·James F SumowskiJohn Deluca
Sep 16, 2009·Archives of Neurology·Nathan P StaffB Mark Keegan
Dec 10, 2009·Multiple Sclerosis : Clinical and Laboratory Research·Valentina ZipoliMaria Pia Amato
Feb 4, 2010·Journal of Behavioral Medicine·Jared M BruceSharon Lynch
Jun 22, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·V DevonshireUNKNOWN GAP Study Group
Jul 17, 2010·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·G MandolesiDiego Centonze
Oct 16, 2010·Progress in Neurobiology·Ranjan Dutta, Bruce D Trapp
Mar 9, 2011·Journal of Neurology·S A MorrowR H B Benedict
Sep 10, 2011·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Nadine AkbarAnthony Feinstein
Dec 23, 2011·Multiple Sclerosis : Clinical and Laboratory Research·D W LangdonR H B Benedict
Jan 6, 2012·Neurology·A SeewannJ J G Geurts
Jan 27, 2012·Multiple Sclerosis : Clinical and Laboratory Research·Ralph H B BenedictDavid Erlanger
Mar 3, 2012·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Russell M BauerRichard I Naugle
Nov 28, 2012·Journal of Neurology·Maria Pia AmatoGiancarlo Comi
Mar 6, 2013·Multiple Sclerosis : Clinical and Laboratory Research·Aurélie RuetBruno Brochet
Apr 25, 2013·Practical Neurology·Peter Owen JenkinsOmar Malik
Jun 25, 2013·Journal of the Neurological Sciences·Y C LearmonthR W Motl
Jul 31, 2013·Multiple Sclerosis : Clinical and Laboratory Research·James F Sumowski, Victoria M Leavitt
Apr 2, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·Matteo PardiniLuca Roccatagliata

❮ Previous
Next ❯

Citations

Dec 7, 2018·International Journal of Clinical Practice·Olga A KleinAvril Drummond
Jun 5, 2020·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Christos BakirtzisNikolaos Grigoriadis
Jan 19, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Paola GrossiMichele Messmer Uccelli
Jun 20, 2019·Frontiers in Neurology·Celia Oreja-GuevaraLluís Ramió-Torrentà
Apr 8, 2020·Auto- Immunity Highlights·Athina AndravizouGeorgios M Hadjigeorgiou
May 10, 2020·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Lambros MessinisPanagiotis Papathanasopoulos
Jun 17, 2021·Journal of the International Neuropsychological Society : JINS·Evgeniy EvdoshenkoGleb Makshakov

❮ Previous
Next ❯

Methods Mentioned

BETA
imaging techniques

Software Mentioned

PASAT
BICAMS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The New England Journal of Medicine
Thomas Berger, Florian Deisenhammer
The New England Journal of Medicine
José C Alvarez-CermeñoLuisa M Villar
Mayo Clinic Proceedings
Melissa M BlessingLori A Erickson
© 2022 Meta ULC. All rights reserved