The ratios of 2nd to 4th digit may be a predictor of schizophrenia in male patients

Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists
Abdullah BoluMehmet Toygar

Abstract

The production of androgens (mostly testosterone) during the early fetal stage is essential for the differentiation of the male brain. Some authors have suggested a relationship between androgen exposure during the prenatal period and schizophrenia. These two separate relationships suggest that digit length ratios are associated with schizophrenia in males. The study was performed in a university hospital between October 2012 and May 2013. One hundred and three male patients diagnosed with schizophrenia according to DSM-IV using SCID-I, and 100 matched healthy males, were admitted to the study. Scale for the Assessment of Positive Symptoms (SAPS), Scale for the Assessment of Negative Symptoms (SANS) and Brief Psychiatric Rating Scale (BPRS) were used to assess schizophrenia symptoms. The second digit (2D) and fourth digit (4D) asymmetry index (AI), and the right- and left-hand 2D:4D ratios were calculated. All parametric data in the groups were compared using an independent t-test. The predictive power of the AI was estimated by receiver operating characteristics analysis. The 2D:4D AI was statistically significantly lower in the patient group than the healthy control comparison group. There were significant differences between...Continue Reading

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Citations

Sep 25, 2017·Frontiers in Medicine·Yoshiki KaneokeToshio Shimokawa
Jan 29, 2021·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Laura Fusar-PoliEugenio Aguglia
Apr 19, 2020·Early Human Development·Sibel GaziogluCavit Boz
Apr 8, 2021·The South African Journal of Psychiatry : SAJP : the Journal of the Society of Psychiatrists of South Africa·Wilhelm D B NieuwoudtEsme Jordaan

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