The reaction of xenogeneic and monoclonal antisera with Reed-Sternberg cells

The Journal of Pathology
A E StuartC S Morris

Abstract

Xenogeneic antisera have been prepared against human monocytes, B lymphocytes and T lymphocytes. The reactivity of these antisera against a variety of normal and neoplastic cells is described. Reed-Sternberg cells from three cases of Hodgkin's disease failed to react with xenogeneic anti-T and anti-monocyte sera, but reacted with an anti-B serum. A further three cases were examined with monoclonal antibodies. Negative results were obtained with monoclonal anti-T and positive results were given by monoclonal antibodies directed against DR and HLA antigens.

References

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Citations

Jul 1, 1984·Journal of Clinical Pathology·C S Morris, A E Stuart
Nov 1, 1985·Journal of Clinical Pathology·A J Norton, P G Isaacson
Jun 1, 1987·Journal of Clinical Pathology·M A HortonT A Lister
Dec 1, 1991·Critical Reviews in Oncology/hematology·L VaickusK A Foon

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