PMID: 6971820Jan 1, 1981

The reactions of the 2'-deoxyadenosine electron adduct in aqueous solution. The effects of the radiosensitizer p-nitroacetophenone. A pulse spectroscopic and pulse conductometric study

International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine
A HissungKlaus-Dieter Asmus

Abstract

The reactions of the one electron adduct of 2'-deoxyadenosine dA(-), in aqueous solutions have been studied using pulse radiolysis techniques with optical absorption and conductivity detection. The dA(-) radical anion itself shows a weak and featureless optical absorption at greater than 300 nm. It reacts rapidly with H20 (k equals 6 x 10(4)M(-1)s(-1); t1/2 equals 210 ns) to yield at least three different protonated structures (dAH., dA'H., dA"H.). In neutral solutions the most important of these (dAH., lambda(max) equals 315 nm) decays by a first order process (t1/2 approximately equal to 9 microseconds). In basic solutions dAH. undergoes on OH- catalysed rearrangement into another neutral radical (dA"'H., lambda(max) equals 355 nm; k(dAH. plus OH-) equals 1.7 x 10(8)M(-1)s(-1)). p-Nitroacetophenone (PNAP) reacts rapidly with the protonated electron adducts of 2'-deoxyadenosine (k equals 5 x 10(9)M(-1)s(-1)). An electron transfer occurs with dAH to yield PNAP and a reoxidized form of 2'-deoxyadenosine. As indicated by its pK value of 8.8 the latter is not, however, simply a repaired 2'-deoxyadenosine molecule, but is suggested to include the elements of water. Species dA"'H.(and dA'H.) react with PNAP in a process which is cle...Continue Reading

References

Citations

Nov 1, 1987·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·K J VisscherJ M Warman
Aug 1, 1995·International Journal of Radiation Biology·M N SchuchmannClemens von Sonntag
Jan 27, 2012·Free Radical Research·Miral Dizdaroglu, Pawel Jaruga
Jun 3, 2014·International Journal of Radiation Biology·Clemens von Sonntag
Mar 22, 2015·Mutation Research. Reviews in Mutation Research·Miral Dizdaroglu

Related Concepts

4-nitroacetophenone
Acetophenones
Conductometry
Deoxyadenosines
Base Excision Repair
Fast Electrons
Pulse Radiolysis
Radiation-Sensitizing Effect

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