The real estate of myoblast cardiac transplantation: negative remodeling is associated with location

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Jonathan D McCueDoris A Taylor

Abstract

Skeletal myoblast transplantation has been proposed as a therapy for ischemic cardiomyopathy owing to its possible role in myogenesis. The relative safety and efficacy based on location within scar is not known. We hypothesized that skeletal myoblasts transplanted into peripheral scar (compared with central scar) would more effectively attenuate negative left ventricular (LV) remodeling but at the risk of arrhythmia. New Zealand White rabbits (n = 34) underwent mid-left anterior descending artery (LAD) ligation to produce a transmural LV infarction. One month after LAD ligation, skeletal myoblasts were injected either in the scar center (n = 13) or scar periphery (n = 10) and compared with saline injection (n = 11). Holter monitoring and magnetic resonance imaging (MRI) was performed pre-injection; Holter monitoring was continued until 2 weeks after injection, with follow-up MRI at 1 month. The centrally treated animals demonstrated increased LV end-systolic volume, end-diastolic volume, and mass that correlated with the number of injected cells. There was a trend toward attenuation of negative LV remodeling in peripherally treated animals compared with vehicle. Significant late ectopy was seen in several centrally injected ani...Continue Reading

References

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Citations

Sep 1, 2008·Journal of Cardiovascular Translational Research·Philippe Menasché
Oct 18, 2008·Diabetes, Obesity & Metabolism·D A Taylor, A G Zenovich
Dec 17, 2009·Circulation·Huei-Sheng Vincent ChenMark Mercola
Nov 19, 2010·Regenerative Medicine·Shazia DurraniKhawaja Husnain Haider
Aug 14, 2009·Expert Review of Cardiovascular Therapy·Juan C Chachques
Oct 13, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mei OuSung Wan Kim
Aug 8, 2009·The Journal of Thoracic and Cardiovascular Surgery·Abdel ShafyJuan C Chachques
Aug 19, 2008·Seminars in Thoracic and Cardiovascular Surgery·Philippe Menasché
May 15, 2009·Journal of Cellular and Molecular Medicine·Sarah FernandesPatricia Lemarchand
Feb 23, 2010·The Annals of Thoracic Surgery·Stacy B O'BlenesMagda Horackova
Feb 20, 2021·Tissue & Cell·Mohammad Reza HashemzadehSeyed Hadi Mousavi
Oct 1, 2008·Drug Discovery Today. Disease Models·Steven M Pogwizd, Donald M Bers

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