The real face of endothelial progenitor cells - Circulating angiogenic cells as endothelial prognostic marker?

Pharmacological Reports : PR
Neli Kachamakova-TrojanowskaAlicja Jozkowicz

Abstract

Endothelial progenitor cells (EPCs) have been extensively studied for almost 19 years now and were considered as a potential marker for endothelial regeneration ability. On the other hand, circulating endothelial cells (CEC) were studied as biomarker for endothelial injury. Yet, in the literature, there is also huge incoherency in regards to terminology and protocols used. This results in misleading conclusions on the role of so called "EPCs", especially in the clinical field. The discrepancies are mainly due to strong phenotypic overlap between EPCs and circulating angiogenic cells (CAC), therefore changes in "EPC" terminology have been suggested. Other factors leading to inconsistent results are varied definitions of the studied populations and the lack of universal data reporting, which could strongly affect data interpretation. The current review is focused on controversies concerning the use of "EPCs"/CAC and CEC as putative endothelial diagnostic markers.

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Citations

Nov 22, 2015·International Journal of Cardiology·Yuan GuoDanyan Xu
Sep 1, 2015·Pharmacological Reports : PR·Stefan Chlopicki
Apr 28, 2018·Journal of Tissue Engineering and Regenerative Medicine·E BaumanC C Barrias
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Jan 19, 2019·Research and Practice in Thrombosis and Haemostasis·Maura FarinacciOliver von Ahsen
Apr 8, 2017·Oxidative Medicine and Cellular Longevity·Laura GiustiLaura Pucci

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