The real informatics challenges of personalized medicine: not just about the number of central processing units

Personalized Medicine
Jonathan Sheldon, Wanmei Ou

Abstract

Personalized medicine has the potential to revolutionize patient care. In order to do so, it requires a re-engineering of many life sciences and healthcare processes, the most significant being the integration of the complete biomarker lifecycle from discovery to targeted treatment of patients. Individual patient omic profiles have become a reality owing to the diminishing cost of DNA sequencing. However, managing these data has created a bottleneck due to: the limitations in storage, computing power and information access; the lack of biologist-friendly software to replace the user-unfriendly custom scripts, which are crippling collaboration; the urgency for standardizing data across omics and clinical data realms for cross-study comparisons; undermining innovations of enterprise and open-source software, which saps innovations of open-source and reliability and support of enterprise software; and unavailability of a robust, integrative workflow system, which leads to actionable data at the patient care level.

References

Dec 6, 2001·Nature Reviews. Genetics·G S Cooke, A V Hill
May 10, 2002·Nature·Lincoln Stein
Sep 20, 2005·Genome Research·Belinda GiardineAnton Nekrutenko
Dec 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·James BeanWilliam Pao
Sep 6, 2008·Nature·UNKNOWN Cancer Genome Atlas Research Network
Dec 25, 2008·The New England Journal of Medicine·Jessica L MegaMarc S Sabatine
Nov 26, 2009·Genome Biology·Ben LangmeadSteven L Salzberg
Sep 18, 2010·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Ch SinningS Blankenberg
Jan 20, 2011·Genome Research·Markus Hsi-Yang FritzEwan Birney
Feb 12, 2011·Science·Scott D Kahn
Mar 11, 2011·Nature Biotechnology·Stephen H Friend, Trey Ideker
Jul 2, 2011·Nature·UNKNOWN Cancer Genome Atlas Research Network
Oct 20, 2011·Nucleic Acids Research·Yuichi KodamaUNKNOWN International Nucleotide Sequence Database Collaboration
Jan 20, 2012·Pharmacogenomics·Matthias SamwaldM Scott Marshall
Apr 7, 2012·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Samuel J AronsonHeidi L Rehm
Jul 20, 2012·Nature·UNKNOWN Cancer Genome Atlas Network
Sep 8, 2012·Nature·UNKNOWN ENCODE Project Consortium

❮ Previous
Next ❯

Citations

Aug 3, 2017·BMC Medical Informatics and Decision Making·Bret S E HealeGuilherme Del Fiol

❮ Previous
Next ❯

Software Mentioned

Galaxy
nbsp

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Dental Hygiene
Maria Perno Goldie
Journal of General Internal Medicine
Richard L Kravitz
Journal of Veterinary Medical Education
Layne M JohnsonLinda A Watson
Methods : a Companion to Methods in Enzymology
© 2022 Meta ULC. All rights reserved