The real-life value of ST2 monitoring during heart failure decompensation: impact on long-term readmission and mortality

Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
Cinta LlibreAntoni Bayes-Genis

Abstract

Prognostic value of ST2 levels and dynamics has not been investigated in acute heart failure (AHF) using prospective real-life measurements. The objective of this study is to investigate the prognostic value of ST2 in AHF. ST2 levels were determined at admission (n = 182) and discharge (n = 85). Primary endpoint was the composite of all-cause death and HF rehospitalisation at one year. Discharge ST2 (HR 2.42 [95% CI 1.46-4], p = 0.001) and ΔST2 (HR 2.32 [95% CI 1.21-4.57], p = 0.01) but not admission ST2, remained independently prognostic for the primary endpoint after comprehensive multivariable adjustment. ST2 significantly improved prognosis stratification on top of clinical variables and NTproBNP. Routine clinical use of discharge ST2 and ST2 dynamics provide independent prognostic information.

References

Nov 11, 2008·Journal of Cardiac Failure·Saskia BoisotRobert L Fitzgerald
Nov 20, 2008·Journal of the American College of Cardiology·Shafiq U RehmanJames L Januzzi
Jun 3, 2010·JAMA : the Journal of the American Medical Association·Héctor BuenoHarlan M Krumholz
Nov 19, 2013·Journal of Cardiac Failure·Tobias BreidthardtChristian Mueller
Dec 3, 2014·Journal of Cardiac Failure·Antoni Bayes-GenisJosep Lupón
Dec 19, 2014·Circulation·Dariush MozaffarianUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Feb 24, 2015·The American Journal of Cardiology·Alexandre MebazaaAntoni Bayes-Genis
Feb 24, 2015·The American Journal of Cardiology·Thomas Mueller, Allan S Jaffe

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Citations

Jan 10, 2017·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Kaspar BrochKristina H Haugaa
Aug 24, 2017·Expert Review of Cardiovascular Therapy·Kay-Won ChangAlan S Maisel

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