The "real-life" variability of CA-125 in ovarian cancer patients

Gynecologic Oncology
Elisa TsoMaurie Markman

Abstract

The serum CA-125 antigen value has proven to be useful in predicting changes that affect prognosis and management of ovarian cancer; however, interpreting variations in the tumor marker is still not well-defined. Our goal was to further understand the analytical variability of CA-125 in a conventional hospital laboratory. In an IRB-approved study, ovarian and primary peritoneal cancer patients receiving active therapy at the Cleveland Clinic Foundation had a blood sample obtained prospectively during a routine clinic visit. The sample was separated into three aliquots then submitted on three different weekdays for CA-125 analysis. Laboratory personnel performing the CA-125 assays had no knowledge that this blood was part of a research study. The CA-125 assay used was a microparticle enzyme immunoassay from Abbott AxSYM system. Fifty-one blood samples were obtained from 45 patients (median age: 62; range: 45-89). The samples were stratified into 3 sub-groups: <100 U/ml (24 samples), 100-600 U/ml (15 samples), and >600 U/ml (12 samples). Analysis of CA-125 consisted of calculating the standard deviations (SD) and coefficients of variations (CV) for each patient's samples. The median SD for CA-125 <100 U/ml was 0.58, mean SD 1.14 ...Continue Reading

References

Jul 1, 1987·American Journal of Obstetrics and Gynecology·I B VergoteV M Abeler
May 1, 1995·Cancer Treatment Reviews·M K TuxenP Dombernowsky
Aug 22, 1996·International Journal of Cancer. Journal International Du Cancer·U HasholznerA Fateh-Moghadam
Feb 24, 2001·Scandinavian Journal of Clinical and Laboratory Investigation·M K TuxenP Dombernowsky

❮ Previous
Next ❯

Citations

May 16, 2012·Archives of Gynecology and Obstetrics·Viroj Wiwanitkit
Apr 28, 2009·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·John P MichaMaurie Markman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

British Journal of Obstetrics and Gynaecology
H B SalvesenO E Iversen
International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
E.J. BradleyE. Calvert
International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
W A A TjalmaD J Cruickshank
© 2021 Meta ULC. All rights reserved