The receptor binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patients

Science Immunology
Lakshmanane PremkumarAravinda M de Silva


The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that first emerged in late 2019 is responsible for a pandemic of severe respiratory illness. People infected with this highly contagious virus can present with clinically inapparent, mild, or severe disease. Currently, the virus infection in individuals and at the population level is being monitored by PCR testing of symptomatic patients for the presence of viral RNA. There is an urgent need for SARS-CoV-2 serologic tests to identify all infected individuals, irrespective of clinical symptoms, to conduct surveillance and implement strategies to contain spread. As the receptor binding domain (RBD) of the spike protein is poorly conserved between SARS-CoVs and other pathogenic human coronaviruses, the RBD represents a promising antigen for detecting CoV-specific antibodies in people. Here we use a large panel of human sera (63 SARS-CoV-2 patients and 71 control subjects) and hyperimmune sera from animals exposed to zoonotic CoVs to evaluate RBD's performance as an antigen for reliable detection of SARS-CoV-2-specific antibodies. By day 9 after the onset of symptoms, the recombinant SARS-CoV-2 RBD antigen was highly sensitive (98%) and specific (100%) for antibodies ...Continue Reading


Oct 22, 2003·Proceedings of the National Academy of Sciences of the United States of America·Boyd YountRalph S Baric
Dec 21, 2004·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·P-R HsuehP-C Yang
Apr 3, 2008·The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale·David M PatrickRobert C Brunham
Feb 10, 2009·Nature Reviews. Microbiology·Lanying DuShibo Jiang
Sep 18, 2013·Proceedings of the National Academy of Sciences of the United States of America·Trevor ScobeyRalph S Baric
Mar 29, 2014·Virus Research·Benjamin MeyerMarcel A Müller
Jun 7, 2017·Emerging Infectious Diseases·Pyoeng Gyun ChoeMyoung-Don Oh
Dec 12, 2018·Nature Reviews. Microbiology·Jie CuiZheng-Li Shi
Mar 22, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Li GuoJianwei Wang
Mar 30, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Juanjuan ZhaoZheng Zhang
Apr 2, 2020·Viruses·Yuefei JinGuangcai Duan
Apr 9, 2020·Emerging Infectious Diseases·Nisreen M A OkbaBart L Haagmans
Apr 25, 2020·The Lancet Infectious Diseases·Amy K Winter, Sonia T Hegde
Apr 30, 2020·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Ranawaka Apm PereraMalik Peiris
May 14, 2020·Nature Medicine·Fatima AmanatFlorian Krammer
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Methods Mentioned

plasma collection

Software Mentioned

GraphPad Prism
PyMOL Molecular Graphics System

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