The receptor mosaic hypothesis of the engram: possible relevance of Boolean network modeling

International Journal of Neural Systems
M ZoliL F Agnati

Abstract

In the past 15 years, several lines of evidence have shown that receptors for chemical signals can interact in domains of the plasma membrane and possibly form molecular circuits encoding logical operators. In this frame, the receptor mosaic hypothesis of the engram was advanced. According to this proposal, aggregates of different receptor species (mosaics) may form in neuronal membranes (typically synapses) and constitute a memory trace (engram) of its activity. In the present paper, we present an attempt to model the functioning of aggregates of interacting receptors in membrane domains by means of random Boolean networks.

Citations

Sep 7, 2006·Journal of Neural Transmission·L F AgnatiK Fuxe
Sep 29, 2005·Proceedings of the National Academy of Sciences of the United States of America·Harel Z Shouval
Mar 6, 2012·The Quarterly Review of Biology·Diego GuidolinLuigi F Agnati
Apr 6, 2007·Brain Research Reviews·Diego GuidolinLuigi F Agnati
Jan 11, 2011·Developmental Biology·Diego GuidolinDomenico Ribatti
Nov 11, 2014·Expert Opinion on Therapeutic Targets·Diego GuidolinKjell Fuxe
May 31, 2011·Molecular Brain·Javier González-Maeso
Oct 27, 2006·Journal of Neural Transmission·K FuxeL F Agnati
May 22, 2019·International Journal of Molecular Sciences·Simone PelassaManuela Marcoli
Mar 6, 2019·Frontiers in Endocrinology·Diego GuidolinLuigi F Agnati

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