The receptor tyrosine kinase EphB2 promotes hepatic fibrosis in mice

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Patrice N MimcheTracey J Lamb

Abstract

Beyond the well-defined role of the Eph (erythropoietin-producing hepatocellular) receptor tyrosine kinases in developmental processes, cell motility, cell trafficking/adhesion, and cancer, nothing is known about their involvement in liver pathologies. During blood-stage rodent malaria infection we have found that EphB2 transcripts and proteins were up-regulated in the liver, a result likely driven by elevated surface expression on immune cells including macrophages. This was significant for malaria pathogenesis because EphB2(-/-) mice were protected from malaria-induced liver fibrosis despite having a similar liver parasite burden compared with littermate control mice. This protection was correlated with a defect in the inflammatory potential of hepatocytes from EphB2(-/-) mice resulting in a reduction in adhesion molecules, chemokine/chemokine receptor RNA levels, and infiltration of leukocytes including macrophages/Kupffer cells, which mediate liver fibrosis during rodent malaria infections. These observations are recapitulated in the well-established carbon tetrachloride model of liver fibrosis in which EphB2(-/-) carbon tetrachloride-treated mice showed a significant reduction of liver fibrosis compared to carbon tetrachlo...Continue Reading

References

Jan 9, 2003·European Journal of Immunology·Nigel SharfeChaim Roifman
Feb 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Josianne NitcheuBehazine Combadiere
Sep 19, 2003·The Journal of Biological Chemistry·Guang YuJiangping Wu
Mar 1, 1960·Transactions of the Royal Society of Tropical Medicine and Hygiene·J H WALTERS, I A McGREGOR
Jan 5, 2005·The Journal of Clinical Investigation·Jeremy S DuffieldJohn P Iredale
Jan 25, 2005·Trends in Parasitology·Christian R EngwerdaFiona H Amante
Jan 27, 2005·Physiological Genomics·Andrei I IvanovAndrej A Romanovsky
Jul 26, 2006·Journal of Leukocyte Biology·Dennis PfaffHellmut G Augustin
Jul 20, 2007·European Journal of Immunology·Hanne S Hjorthaug, Hans-Christian Aasheim
Nov 6, 2007·Molecular Immunology·Nigel SharfeChaim M Roifman
Dec 17, 2008·Expert Review of Gastroenterology & Hepatology·Karlin Raja KarlmarkFrank Tacke
Feb 12, 2009·Annals of Tropical Medicine and Parasitology·A B Rupani, A D Amarapurkar
Jun 26, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Karlin Raja KarlmarkFrank Tacke
Jul 29, 2010·Seminars in Liver Disease·Thomas A Wynn, Luke Barron
Nov 3, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Karlin Raja KarlmarkFrank Tacke
Dec 4, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Jennifer BraunThomas Korff
Mar 15, 2011·Human Pathology·Richard WhittenTerrie E Taylor
Apr 26, 2011·The American Journal of Pathology·Katerina Dorovini-ZisTerrie E Taylor
Oct 28, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Felix HeymannFrank Tacke
Mar 13, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yoshiaki SunamiThomas Wirth
Jun 23, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ana Villegas-MendezKevin N Couper
Oct 27, 2012·Proceedings of the National Academy of Sciences of the United States of America·Prakash RamachandranJohn P Iredale
Apr 5, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jean-Philippe PradereRobert F Schwabe
Aug 28, 2013·Medical Hypotheses·Yuri Chaves Martins, Cláudio Tadeu Daniel-Ribeiro
Nov 28, 2013·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Paul D PozniakKamel Khalili
Dec 4, 2013·Genes & Development·Akiko NakayamaRalf H Adams
Jul 22, 2014·Nature Communications·Inmaculada Lopez-SanchezPradipta Ghosh

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Citations

Sep 13, 2015·Metabolism: Clinical and Experimental·Jing-Jing YangJun Li
Apr 29, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Noah S Butler, Nathan W Schmidt
Jan 31, 2020·PLoS Pathogens·Thayer K DarlingTracey J Lamb
Dec 28, 2016·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Jing-Jing YangJun Li
Apr 14, 2019·Current Rheumatology Reports·Brian WuMohit Kapoor
Aug 28, 2020·Frontiers in Physiology·Jun MinShankar Subramaniam
Jul 25, 2019·Frontiers in Immunology·Thayer K Darling, Tracey J Lamb
Jul 6, 2020·Molecular Biology Reports·Max London, Eugenio Gallo
May 10, 2021·Cellular and Molecular Gastroenterology and Hepatology·David J MatyeTiangang Li
Sep 1, 2021·Clinical Science·Zhimin HuangYufeng Huang

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