The receptor tyrosine kinase RON represses HIV-1 transcription by targeting RNA polymerase II processivity

The Journal of Immunology : Official Journal of the American Association of Immunologists
Alicia KlattAndrew J Henderson

Abstract

Efficient HIV-1 transcription requires the induction of cellular transcription factors, such as NF-kappaB, and the viral factor Tat, which through the recruitment of P-TEFb enhances processive transcription. However, whether cellular signals repress HIV-1 transcription to establish proviral latency has not been well studied. Previously, it has been shown that the receptor tyrosine kinase RON inhibits HIV transcription. To gain insights into the biochemical mechanisms by which RON inhibits transcription we examined the binding of transcription factors to the HIV provirus long terminal repeat using chromatin immunoprecipitation. RON expression decreased basal levels of NF-kappaB and RNA polymerase II (Pol II) binding to the HIV provirus long terminal repeat but did not prevent the induction of these complexes following treatment with cytokines. However, RON did decrease efficient transcription elongation because reduced RNA Pol II was associated with HIV-1 genomic sequences downstream of the transcriptional start site. There was a correlation between RON expression and increased binding of factors that negatively regulate transcription elongation, NELF, Spt5, and Pcf11. Furthermore, the ability of RON to inhibit HIV-1 transcripti...Continue Reading

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Citations

Nov 23, 2010·Cell Cycle·Ruma MukerjeeBassel E Sawaya
Jul 9, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Parisa KalantariAndrew J Henderson
Oct 6, 2009·Journal of Leukocyte Biology·Laetitia RedelChristian Schwartz
Sep 18, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daniele C CaryAndrew J Henderson
Jan 13, 2018·Microbiology and Molecular Biology Reviews : MMBR·Jean-François GélinasStephen C Hyde
Apr 8, 2020·World Journal of AIDS·William De MartiniSulie L Chang
Apr 13, 2010·Retrovirology·Valentin Le DouceChristian Schwartz

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