The reciprocal relationship between primordial germ cells and pluripotent stem cells.

Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte
Mehdi PirouzMichael Kessel

Abstract

Primordial germ cells (PGCs) are induced in the epiblast early in mammalian development. They develop their specific fate separate from somatic cells by the generation of a unique transcriptional profile and by epigenetic modifications of histones and DNA. PGCs are related to pluripotent cells in many respects, both on a molecular and a cell biological level. Mimicking their in vivo development, PGCs can be derived in culture from pluripotent cells. Vice versa, PGCs can be converted in vitro into pluripotent embryonic germ cells. Recent evidence indicates that the derivation of pluripotent embryonic stem cells from explanted inner cell mass cells may pass through a germ cell-like state, but that this intermediate is not obligatory. In this review, we discuss PGC development and its relevance to pluripotency in mammalian embryos. We outline possibilities and problems connected to the application of in vitro-derived germ cells in reproductive medicine.

References

Nov 6, 1998·Science·J A ThomsonJ M Jones
Nov 13, 1998·Proceedings of the National Academy of Sciences of the United States of America·M J ShamblottJ D Gearhart
Jan 7, 2000·Journal of Cellular Physiology·A McLaren
May 6, 2003·Science·Karin HübnerHans R Schöler
Sep 25, 2003·Proceedings of the National Academy of Sciences of the United States of America·Yayoi ToyookaToshiaki Noce
Oct 4, 2003·Molecular Endocrinology·Gerd H G Moe-BehrensMassimo De Felici
Dec 29, 2004·Cell·Mito Kanatsu-ShinoharaTakashi Shinohara
Dec 30, 2004·Development·Thomas P Zwaka, James A Thomson
Jun 7, 2005·Nature·Yasuhide OhinataM Azim Surani
Sep 13, 2005·Cell·Laurie A BoyerRichard A Young
Dec 15, 2005·Differentiation; Research in Biological Diversity·Anne McLaren, Kirstie A Lawson
Nov 23, 2006·Mechanisms of Development·Brian M DudleyKathleen Molyneaux
May 2, 2007·Genes & Development·Andrea SmallwoodMichael Carey
Nov 21, 2007·Current Opinion in Biotechnology·Marc Lewitzky, Shinya Yamanaka
Dec 22, 2007·BMC Developmental Biology·Susana M Chuva de Sousa LopesM Azim Surani
Jan 17, 2008·Nature Reviews. Genetics·Hiroyuki Sasaki, Yasuhisa Matsui
Jan 18, 2008·Biology of Reproduction·Mito Kanatsu-ShinoharaTakashi Shinohara
May 24, 2008·Nature·Qi-Long YingAustin Smith
Jul 16, 2008·Nature Genetics·Masashi YamajiMitinori Saitou
Jul 16, 2008·Current Opinion in Genetics & Development·Yumiko Saga
Oct 14, 2008·Nature·Sabine ConradThomas Skutella
Oct 28, 2008·PloS One·Gabriela Durcova-HillsM Azim Surani
Dec 25, 2008·PloS One·Wei WeiHongkui Deng
Mar 11, 2009·Frontiers in Bioscience (Landmark Edition)·Mitinori Saitou
Mar 14, 2009·Stem Cells and Development·Nady GolestanehMartin Dym
Jul 3, 2009·Cell Stem Cell·Kinarm KoHans R Schöler
Jul 21, 2009·Current Opinion in Genetics & Development·Mitinori Saitou

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Citations

Jun 20, 2012·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Daniel Besser
Sep 7, 2013·PLoS Genetics·Mehdi PirouzMichael Kessel
Jan 23, 2014·Human Molecular Genetics·Jens Durruthy DurruthyRenee A Reijo Pera
May 1, 2015·Cell Cycle·Mehdi PirouzMichael Kessel
Oct 29, 2017·Stem Cells and Development·Seema C ParteSham S Kakar
Aug 12, 2016·Reproduction : the Official Journal of the Society for the Study of Fertility·Daniel NettersheimHubert Schorle
Jun 30, 2016·International Journal of Molecular Medicine·Yinshan BaiNingfang Ma

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