PMID: 2494293Mar 1, 1989Paper

The reconstitution of cell-mediated immunity in the cutaneous lesions of lepromatous leprosy by recombinant interleukin 2

The Journal of Experimental Medicine
G KaplanM Dietz

Abstract

Human rIL-2 (10-30 micrograms) was injected intradermally into the skin of patients with lepromatous leprosy with high bacillary loads. All patients responded to the lymphokine with local areas of induration that peaked at 24 h and persisted for 4-7 d irrespective of whether the site was "normal skin" or a nodular lesion. Within 24 h there was an extensive emigration of T cells and monocytes into the site. The percentage of the dermis infiltrated by mononuclear cells increased by more than sevenfold, peaking at 4 d and persisting for greater than 15 d. Both CD4+ and CD8+ T cells entered the site. T cells of CD4+ phenotype predominated at 2-7 d but by 11 d, CD8+ cells were predominant. Considerable numbers of T6+ Langerhans' cells appeared in the dermis by 72 h and persisted for 3 wk. By 4 d the thickness of the overlying epidermis had increased twofold, and keratinocytes were expressing MHC class II antigen and the IFN-gamma-induced peptide IP-10. Starting at 48 h, there was an extensive destruction of mononuclear phagocytes that contained structurally intact or fragmented M. leprae observed at the electron microscope level. The organisms, either free or contained within endocytic vacuoles, were discharged into the extracellula...Continue Reading

References

Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·G KaplanZ A Cohn
Oct 1, 1988·The Journal of Experimental Medicine·A R NusratZ A Cohn
May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·G KaplanZ A Cohn
Jun 1, 1988·The Journal of Experimental Medicine·M J McElrathZ A Cohn
Jun 1, 1987·The Journal of Clinical Investigation·C WeyandP O'Hanley
Jul 1, 1985·The Journal of Experimental Medicine·H KawamuraJ A Berzofsky
Sep 1, 1985·The Journal of Experimental Medicine·G KaplanZ A Cohn
Dec 1, 1974·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·I W McLean, P K Nakane
Nov 1, 1981·The Journal of Clinical Investigation·A NakagawaraZ A Cohn
Dec 1, 1983·The Journal of Experimental Medicine·N NogueiraR Steinman
Jan 1, 1984·Annual Review of Immunology·K A Smith
Jan 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·R L EvansR A Good
Apr 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·E FithianR Edelson
Mar 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·E G EnglemanR Levy

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Citations

Jan 1, 1993·Archives of Dermatological Research·M AkiyamaT Nishikawa
Sep 1, 1990·Diagnostic Microbiology and Infectious Disease·J L KrahenbuhlG T Chae
Sep 1, 1990·Diagnostic Microbiology and Infectious Disease·S H Kaufmann
Feb 1, 1989·Current Opinion in Immunology·S H Kaufmann
Feb 1, 1991·Current Opinion in Immunology·G Kaplan, Z A Cohn
Oct 1, 1996·Research in Immunology·G Kaplan, V H Freedman
Oct 1, 1996·Research in Immunology·S M Holland
Jan 1, 1995·Trends in Microbiology·L E Bermudez, G Kaplan
Aug 1, 1992·Immunology and Cell Biology·R J MullinsA Basten
Feb 1, 1992·Bio/technology·G KaplanK A Smith
Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·G KaplanE N Sarno
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·G KaplanZ A Cohn
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M J McElrathZ A Cohn
Apr 1, 1991·The Journal of Experimental Medicine·G KaplanJ Barker
Jun 1, 1993·The Journal of Experimental Medicine·A MolloyG Kaplan
Jan 1, 1994·The Journal of Experimental Medicine·R M Steinman, C L Moberg
Oct 6, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Nina Singh, John R Perfect
Jun 1, 1995·European Journal of Clinical Investigation·T H Ottenhoff, T Mutis
Oct 1, 1994·International Journal of Dermatology·V N Sehgal, S Jain
Apr 15, 2006·Clinical Microbiology Reviews·D M ScollardD L Williams
Apr 19, 2003·American Journal of Respiratory and Critical Care Medicine·John L JohnsonUNKNOWN Uganda-Case Western Reserve University Research Collaboration
Mar 1, 1996·The Journal of Clinical Investigation·A KumarF Triebel
Feb 1, 1992·Immunobiology·S H Kaufmann, D B Young
Sep 15, 2005·Annals of Tropical Paediatrics·Luis E Cuevas, Ai Koyanagi
Dec 18, 2012·Periodontology 2000·Gary C Armitage
Jan 18, 2005·Current Opinion in Immunology·Alexandre AlcaïsLaurent Abel
Aug 1, 1998·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·E P Sampaio, E N Sarno

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