The recovery of illicit drugs from oral fluid sampling devices

Forensic Science International : Synergy
Stuart DicksonScott Hampton

Abstract

Testing for drugs in oral fluid is a convenient procedure for determining recent drug use. A number of issues are still to be resolved and this paper investigates the effects of storage systems on drug stability and recovery using three different collection devices supplied by Cozart, Immunalysis and Microgenics (third party). Drugs were analysed using a range of immunoassay systems followed by MS confirmation and quantitation. The reproducibility of the weight of specimen collected was excellent (CV<10%) for the three collection devices tested. Of the three systems studied, only the Cozart product gave acceptable recovery of THC from drug-spiked oral fluid. A combination of Cozart, Immunalysis and Diagnostix immunoassays with the Cozart collection system gave the most sensitive and discriminating screening assays for the drugs studied, namely THC, benzodiazepines, methamphetamine and morphine. Storage at either 5 degrees C or room temperature had no significant effect on drug recoveries.

References

May 19, 2005·Forensic Science International : Synergy·Dennis J Crouch
Jun 10, 2005·Forensic Science International : Synergy·Pascal KintzVincent Cirimele

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Citations

Sep 12, 2009·Clinical Chemistry·Wendy M Bosker, Marilyn A Huestis
Aug 9, 2011·Legal Medicine·Amparo ArroyoAgustí Mora
Mar 14, 2009·Forensic Science International : Synergy·Jürgen KempfWolfgang Weinmann
Jul 13, 2007·Forensic Science International : Synergy·T SpeedyA Jehanli
May 1, 2007·Forensic Science International : Synergy·Susan Nolan
Mar 31, 2007·Journal of Pharmaceutical and Biomedical Analysis·Mitona PujadasRafael de la Torre
Mar 26, 2016·Journal of Analytical Toxicology·Vigdis VindenesHallvard Gjerde
Mar 18, 2015·Journal of Pharmaceutical and Biomedical Analysis·Karolina PersonaWojciech Piekoszewski
Oct 25, 2014·Journal of Analytical Toxicology·Ashley-Jane HallWendy E Ferguson
Sep 30, 2016·Journal of Analytical Toxicology·Camille CohierOlivier Roussel
Mar 28, 2008·Therapeutic Drug Monitoring·Kristof Pil, Alain Verstraete
Apr 4, 2007·Analytical and Bioanalytical Chemistry·Nele SamynGert De Boeck
Jul 3, 2019·Journal of Analytical Toxicology·Nathalie A Desrosiers, Marilyn A Huestis
Aug 1, 2012·Therapeutic Drug Monitoring·Eloisa ComiranRenata Pereira Limberger
Mar 25, 2009·Therapeutic Drug Monitoring·Montse VenturaRafael de la Torre
May 23, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Rebeca Alonso-AriasCarlos López-Larrea

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