The recurrence of leprosy reactional episodes could be associated with oral chronic infections and expression of serum IL-1, TNF-alpha, IL-6, IFN-gamma and IL-10

Brazilian Dental Journal
Ana Carolina F MottaNorma T Foss

Abstract

The aim of this study was to determine whether the presence of leprosy reactional episodes could be associated with chronic oral infection. Thirty-eight leprosy patients were selected and divided into 2 groups: group I - 19 leprosy patients with oral infections, and group II - 19 leprosy patients without oral infections. Ten patients without leprosy, but presenting oral infections, were assigned to the control group. Leprosy patients were classified according to Ridley and Jopling classification and reactional episodes of the erythema nodosum type or reversal reaction were identified by clinical and histopathological features associated with serum IL-1, TNF-alpha, IL-6, IFN-gamma and IL-10 levels. These analyses were performed immediately before and 7 days after the oral infection elimination. Patients from group I presenting oral infections reported clinical improvement of the symptoms of reactional episodes after dental treatment. Serum IL-1, TNF-alpha, IL-6, IFN-gamma and IL-10 levels did not differ significantly before and after dental treatment as determined by the Wilcoxon test (p>0.05). Comparison of the 2 groups showed statistically significant differences in IL-1 and IL-6 at baseline and in IL-1, IL-6 and IL-10 on the ...Continue Reading

References

Aug 2, 2001·The Journal of the American Dental Association·M K JeffcoatJ C Hauth
Jan 30, 2004·Cytokine & Growth Factor Reviews·Simone MocellinMario Lise
Jun 5, 2007·Seminars in Cutaneous Medicine and Surgery·Jesús CuevasFélix Contreras
May 6, 2008·Journal of Periodontology·Patricia A A O'ConnellMarcio F M Grisi

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Citations

Nov 7, 2012·Indian Dermatology Online Journal·Shambulingappa PallagattiRavinder Singh
Feb 11, 2012·Medicina oral, patología oral y cirugía bucal·Jamileh-Bigom TaheriSomayeh Alirezaei
Jan 11, 2013·Memórias do Instituto Oswaldo Cruz·Paulo Roberto Lima MachadoMarshall J Glesby
Oct 28, 2011·Revista Da Sociedade Brasileira De Medicina Tropical·Ana Carolina Fragoso MottaNorma Tiraboschi Foss
Apr 9, 2013·Revista Da Sociedade Brasileira De Medicina Tropical·Ana Carolina Fragoso MottaNorma Tiraboschi Foss
Feb 7, 2017·Infectious Diseases of Poverty·Adriana Barbosa de Lima FonsecaAmelia Ribeiro de Jesus
Nov 15, 2018·Revista Do Instituto De Medicina Tropical De São Paulo·Denise Costa Boamorte CortelaEliane Ignotti
Feb 11, 2015·Expert Review of Clinical Immunology·Priscila Ribeiro AndradeEuzenir Nunes Sarno
Oct 15, 2014·Asian Pacific Journal of Tropical Medicine·Aravindhan Thiruputkuzhi RanganathanLakshmiganthan Mahalingam
Mar 30, 2017·Frontiers in Immunology·Anastasia PolycarpouDiana N J Lockwood
Jun 20, 2018·Frontiers in Immunology·Mayara Garcia de Mattos BarbosaRoberta Olmo Pinheiro
Sep 9, 2016·Oral Diseases·G A RodriguesAcf Motta

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