The recycling endosome and bacterial pathogens

Cellular Microbiology
Samual C Allgood, M Ramona Neunuebel

Abstract

Bacterial pathogens have developed a wide range of strategies to survive within human cells. A number of pathogens multiply in a vacuolar compartment, whereas others can rupture the vacuole and replicate in the host cytosol. A common theme among many bacterial pathogens is the use of specialised secretion systems to deliver effector proteins into the host cell. These effectors can manipulate the host's membrane trafficking pathways to remodel the vacuole into a replication-permissive niche and prevent degradation. As master regulators of eukaryotic membrane traffic, Rab GTPases are principal targets of bacterial effectors. This review highlights the manipulation of Rab GTPases that regulate host recycling endocytosis by several bacterial pathogens, including Chlamydia pneumoniae, Chlamydia trachomatis, Shigella flexneri, Salmonella enterica serovar Typhimurium, Uropathogenic Escherichia coli, and Legionella pneumophila. Recycling endocytosis plays key roles in a variety of cellular aspects such as nutrient uptake, immunity, cell division, migration, and adhesion. Though much remains to be understood about the molecular basis and the biological relevance of bacterial pathogens exploiting Rab GTPases, current knowledge supports t...Continue Reading

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Citations

Dec 6, 2018·Toxins·Byoung Sik Kim
Aug 28, 2020·International Journal of Molecular Sciences·Mary J O'Sullivan, Andrew J Lindsay
Mar 23, 2021·Frontiers in Cell and Developmental Biology·Xin YongDa Jia
May 21, 2021·Journal of Cell Science·Mariana De NizCarolina Agop-Nersesian
Jun 3, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Emily XuAlexandra S Piotrowski-Daspit

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