The red blood cell glutathione reductase activity in anaemic rats

Mechanisms of Ageing and Development
K Spodaryk


The enzyme activity of glutathione reductase (GR, EC was measured in rat red blood cells separated centrifugally in a density gradient of Percoll. The animals were divided into three groups: Groups IPHH, anaemia was induced by administration of phenylhydrazine hydrochloride; Group IITr, anaemia was induced by intense physical training; and Group C, control group. The activity of active and inactive forms of GR were higher in erythrocytes of animals from groups IPHH and IITr, both in young and old forms of cells, than in red cells of control rats, the degree of decrease in activity of both forms of GR in senescent red cells is similar in different kinds of anaemia.


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