The redox switch that regulates molecular chaperones

Biomolecular Concepts
Myra E Conway, Christopher Lee

Abstract

Modification of reactive cysteine residues plays an integral role in redox-regulated reactions. Oxidation of thiolate anions to sulphenic acid can result in disulphide bond formation, or overoxidation to sulphonic acid, representing reversible and irreversible endpoints of cysteine oxidation, respectively. The antioxidant systems of the cell, including the thioredoxin and glutaredoxin systems, aim to prevent these higher and irreversible oxidation states. This is important as these redox transitions have numerous roles in regulating the structure/function relationship of proteins. Proteins with redox-active switches as described for peroxiredoxin (Prx) and protein disulphide isomerase (PDI) can undergo dynamic structural rearrangement resulting in a gain of function. For Prx, transition from cysteine sulphenic acid to sulphinic acid is described as an adaptive response during increased cellular stress causing Prx to form higher molecular weight aggregates, switching its role from antioxidant to molecular chaperone. Evidence in support of PDI as a redox-regulated chaperone is also gaining impetus, where oxidation of the redox-active CXXC regions causes a structural change, exposing its hydrophobic region, facilitating polypeptid...Continue Reading

References

Feb 1, 1992·Antonie van Leeuwenhoek·S J Hardy, L L Randall
Jan 2, 1992·Nature·M J Gething, J Sambrook
Apr 30, 1966·Nature·M Y Karpeisky, V I Ivanov
Jul 15, 1995·European Journal of Biochemistry·J L Song, C C Wang
Mar 7, 2001·Antioxidants & Redox Signaling·H T KimG Perry
Apr 24, 2002·Biochemistry·Zachary A WoodP Andrew Karplus
May 30, 2002·Biological Chemistry·Birgit HofmannLeopold Flohé
Jul 31, 2002·Molecular Pathology : MP·J C Ranford, B Henderson
Dec 18, 2002·The EMBO Journal·Richard A Lumb, Neil J Bulleid
Jan 9, 2003·Trends in Biochemical Sciences·Zachary A WoodLeslie B Poole
Sep 11, 2003·American Journal of Physiology. Endocrinology and Metabolism·Andrew J SweattSusan M Hutson
Feb 20, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jordi MagranéHenry W Querfurth
May 26, 2004·Biochimica Et Biophysica Acta·Bonney Wilkinson, Hiram F Gilbert
Nov 5, 2004·Proteomics·Manuela BassoMauro Fasano
Sep 10, 2005·The Journal of Biological Chemistry·Mariano JaniszewskiFrancisco R M Laurindo
Apr 12, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·Wulf Dröge
Jul 21, 2006·Molecular & Cellular Proteomics : MCP·Jinghua JinJing Zhang
Oct 13, 2006·Antioxidants & Redox Signaling·Vittorio CalabreseD A Butterfield
Oct 20, 2006·The Journal of Biological Chemistry·Neela H YennawarSusan M Hutson
Jan 2, 2007·Biochemical and Biophysical Research Communications·Tania MassignanValentina Bonetto
May 18, 2007·Molecular Biology of the Cell·Marcel van LithAdam M Benham
Jul 7, 2007·The Journal of Biological Chemistry·Henri H Versteeg, Wolfram Ruf
Jul 17, 2007·Trends in Biochemical Sciences·Pierre Goloubinoff, Paolo De Los Rios

❮ Previous
Next ❯

Citations

Sep 17, 2016·Experimental Biology and Medicine·Suet-Hui OwBoon-Huat Bay
Sep 15, 2018·Journal of Neurochemistry·D Allan Butterfield, Debra Boyd-Kimball
Jul 9, 2020·Antioxidants & Redox Signaling·Myra Elizabeth Conway
Oct 21, 2016·Acta neurologica Belgica·Vittorio GovoniEnrico Granieri
Feb 10, 2019·Nature Communications·Filipa TeixeiraUrsula Jakob
Aug 10, 2019·Proceedings of the National Academy of Sciences of the United States of America·Ekaterina I BiterovaLloyd W Ruddock
Oct 2, 2020·International Journal of Molecular Sciences·Kyung Hee LeeBae Hwan Lee
Jun 19, 2019·Oxidative Medicine and Cellular Longevity·Giovanna CeniniRoberta Cascella
Apr 3, 2019·Proceedings of the National Academy of Sciences of the United States of America·Jean DefournyChristine Petit
Apr 5, 2018·Frontiers in Physiology·Claudia PennaMara Brancaccio

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amyloid Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a progressive nervous system disease associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.