The reduced genome of the parasitic microsporidian Enterocytozoon bieneusi lacks genes for core carbon metabolism.

Genome Biology and Evolution
Patrick J KeelingSaul Tzipori

Abstract

Reduction of various biological processes is a hallmark of the parasitic lifestyle. Generally, the more intimate the association between parasites and hosts the stronger the parasite relies on its host's physiology for survival and reproduction. However, some systems have been held to be indispensable, for example, the core pathways of carbon metabolism that produce energy from sugars. Even the most hardened anaerobes that lack oxidative phosphorylation and the tricarboxylic acid cycle have retained glycolysis and some downstream means to generate ATP. Here we describe the deep-coverage genome resequencing of the pathogenic microsporidiian, Enterocytozoon bieneusi, which shows that this parasite has crossed this line and abandoned complete pathways for the most basic carbon metabolism. Comparing two genome sequence surveys of E. bieneusi to genomic data from four other microsporidia reveals a normal complement of 353 genes representing 30 functional pathways in E. bieneusi, except that only 2 out of 21 genes collectively involved in glycolysis, pentose phosphate, and trehalose metabolism are present. Similarly, no genes encoding proteins involved in the processing of spliceosomal introns were found. Altogether, E. bieneusi appe...Continue Reading

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Citations

Jul 18, 2012·Proceedings of the National Academy of Sciences of the United States of America·Jean-François PombertPatrick J Keeling
Dec 24, 2010·Briefings in Functional Genomics·Nicolas Corradi, Claudio H Slamovits
Nov 22, 2013·Genome Biology and Evolution·Sirintra NakjangT Martin Embley
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Mar 1, 2016·BMC Evolutionary Biology·Rafał MilanowskiBożena Zakryś

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Datasets Mentioned

BETA
SRX019563

Methods Mentioned

BETA
454 Life Sciences shotgun sequencing

Software Mentioned

Blast
TBlastN
Roche
GLIMMER3
Newbler assembler
EMBOSS

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