The reduction in treatment efficiency at high acoustic powers during MR-guided transcranial focused ultrasound thalamotomy for Essential Tremor

Medical Physics
Alec HughesK Hynynen

Abstract

To analyze clinical data indicating a reduction in the induced energy-temperature efficiency relationship during transcranial focused ultrasound (FUS) Essential Tremor (ET) thalamotomy treatments at higher acoustic powers, establish its relationship with the spatial distribution of the focal temperature elevation, and explore its cause. A retrospective observational study of patients (n = 19) treated between July 2015 and August 2016 for (ET) by FUS thalamotomy was performed. These data were analyzed to compare the relationships between the applied power, the applied energy, the resultant peak temperature achieved in the brain, and the dispersion of the focal volume. Full ethics approval was received and all patients provided signed informed consent forms before the initiation of the study. Computer simulations, animal experiments, and clinical system tests were performed to determine the effects of skull heating, changes in brain properties and transducer acoustic output, respectively. All animal procedures were approved by the Animal Care and Use Committee and conformed to the guidelines set out by the Canadian Council on Animal Care. MATLAB was used to perform statistical analysis. The reduction in the energy efficiency rela...Continue Reading

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Citations

Apr 17, 2019·Journal of Magnetic Resonance Imaging : JMRI·Jaime Caballero-InsaurriagaJosé A Pineda-Pardo
May 30, 2019·Scientific Reports·Steven A LeungKim Butts Pauly
Nov 7, 2019·Neurosurgery·Vibhor KrishnaCasey Halpern
Aug 21, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Ryan M JonesKullervo Hynynen
Nov 10, 2020·Neurologia Medico-chirurgica·Kazuaki YamamotoTakaomi Taira
Dec 1, 2019·Physical Review Research·Nathan McDannoldRees Cosgrove
Dec 31, 2019·Clinical Parkinsonism & Related Disorders·María Carolina Sepúlveda Soto, Alfonso Fasano
Nov 10, 2021·Brain : a Journal of Neurology·David J SegarG Rees Cosgrove

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