The reduction of melatonin levels is associated with the development of preeclampsia: a meta-analysis

Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy
Yuanyan DouJing Wu

Abstract

The aim of this analysis was to demonstrate the association between melatonin levels and the development of preeclampsia. Standardized mean difference (SMD) with 95% confidence interval (CI) was calculated using a random effects model. The pooled SMD between case and control was 1.40 (95% CI: 0.26, 2.55; P = 0.02). And the pooled SMD between mild PE and severe PE was 5.25 (95% CI: 1.5, 9.01; P = 0.006). The meta-analysis illustrated that melatonin concentration was significantly lower in women with preeclampsia, and correlated with the severity of the disease.

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Mar 27, 2020·Frontiers in Endocrinology·James M Olcese
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