The reduction of preoperative autologous blood donation for primary total hip or knee arthroplasty: the effect on subsequent transfusion rates

Anesthesia and Analgesia
Claude CouvretJacques Fusciardi

Abstract

We conducted this quality assurance observational study to examine the effects of a change in policy regarding preoperative autologous blood donation (PABD) and indications for perioperative blood transfusion in patients undergoing primary total hip or knee arthroplasty. Two successive time periods, each including 182 successive patients treated by the same medical team and with standardized anesthesia, were compared. The first study had the following standard transfusion policy: 3 U of PABD collected (n = 119) and liberal autologous transfusion (AT). The second study introduced a specific indication for PABD, on the basis of estimated red blood cell reserve and a life expectancy of more than 10 years; 2 U of PABD was collected (n = 81), and criteria were identical for AT and allogeneic transfusion. We mainly compared the incidence of AT; allogeneic and overall transfusions; the inclusion, admission, and discharge hematocrit values; and the wastage of PABD units. This novel policy increased the number of untransfused patients by a factor of 10 (5.5% vs 56.6%) (P < 0.0001), decreased the number of PABD patients by 30% with a 2.4-fold reduction in AT (30% vs 80%) (P < 0.0001), and did not change allogeneic requirements (13% vs 15...Continue Reading

References

Mar 1, 1992·Annals of Internal Medicine·H G WelchL T Goodnough
Mar 16, 1995·The New England Journal of Medicine·J EtchasonR Brook
Mar 1, 1996·Archives of Physical Medicine and Rehabilitation·D GreenD Ronin
Feb 1, 1996·Transfusion·G A NuttallS Bryant
Jan 1, 1996·Current Medical Research and Opinion·F Mercuriali, G Inghilleri
May 1, 1997·Transfusion·J V Linden, M S Kruskall
May 1, 1997·Transfusion·M GoldmanF Décary
Feb 11, 1999·The New England Journal of Medicine·L T GoodnoughJ P AuBuchon
Feb 11, 1999·The Journal of Bone and Joint Surgery. American Volume·B E BierbaumR B Welch
Feb 18, 1999·The New England Journal of Medicine·L T GoodnoughJ P AuBuchon
Jun 22, 2000·Anesthesiology·D R Spahn, M Casutt

❮ Previous
Next ❯

Citations

Jul 28, 2007·Transfusion·Hans GombotzAxel Hofmann
Jan 7, 2016·The Bone & Joint Journal·E P Su, S Su
Mar 12, 2008·Expert Review of Medical Devices·German A MarulandaMichael A Mont
Jan 1, 2014·Revista Brasileira De Ortopedia·Felipe RothCarlos Roberto Schwartsmann
May 11, 2021·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·Filippo MiglioriniMarcel Betsch
Aug 1, 2006·Neurosurgery Clinics of North America·R Shay Bess, Lawrence G Lenke

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.