Abstract
B-Lymphocyte-activating factor (BAFF/BLyS) is a survival factor for B cells, belonging to the tumor necrosis ligand super family. Serum BAFF levels have been found to be elevated in patients with systemic lupus erythematosus (SLE). Neutralization of BAFF activity was suggested as an additional therapeutic approach in SLE. To determine the effect of add-on Quinacrine (Qn) treatment on serum BAFF levels and the effect of this treatment on SLE disease activity index (SLEDAI), antidsDNA and anticardiolipin (aCL) antibody levels, we treated 29 stable SLE patients, who were maintained on prednisolone and hydroxychloroquine and in some on azathioprine (AZT), with additional Qn (100 mg/d) with an aim to further reduce disease activity. SLEDAI, antidsDNA, aCL antibodies and serum BAFF levels were assessed before and 3 months after the addition of Qn. Three months following Qn initiation, a reduction in SLEDAI was noticed in 19/29 patients (mean 8.8 +/- 2.3 to 3.3 +/- 1.5, P = 0.009), followed by reduction or discontinuation of prednisolone in all patients and the discontinuation of AZT in five patients. Serum BAFF levels were significantly reduced in 8/12 patients (mean 6.3 +/- 0.5 to 3.0 +/- 0.56 ng/ml P = 0.0001). This reduction was f...Continue Reading
References
Jun 1, 1992·Arthritis and Rheumatism·C BombardierC H Chang
Nov 1, 1982·Arthritis and Rheumatism·E M TanR J Winchester
Jan 1, 1995·Dermatology : International Journal for Clinical and Investigative Dermatology·D LipskerC Frances
Jan 1, 1994·Dermatology : International Journal for Clinical and Investigative Dermatology·R FeldmannJ H Saurat
Oct 1, 1993·Seminars in Arthritis and Rheumatism·R I Fox
Jun 8, 1999·The Journal of Experimental Medicine·P SchneiderJ Tschopp
Mar 15, 2000·Proceedings of the National Academy of Sciences of the United States of America·S D KhareH Hsu
Apr 29, 2000·Lupus·E ToubiT D Golan
Jul 6, 2000·Lupus·D J WallaceN Pashinian
Jan 3, 2001·Blood·B NardelliD M Hilbert
Jan 9, 2001·Cytokine·P KanakarajJ Giri
Jun 16, 2001·Arthritis and Rheumatism·G S CheemaW Stohl
Aug 25, 2001·Immunity·J A GrossC H Clegg
Feb 28, 2002·Trends in Immunology·Fabienne Mackay, Charles R Mackay
Mar 1, 2002·Current Opinion in Immunology·Antonius G Rolink, Fritz Melchers
Apr 27, 2002·Nature Immunology·Arthur M Krieg
Aug 8, 2002·Clinical Immunology : the Official Journal of the Clinical Immunology Society·William StohlDavid M Hilbert
Jan 16, 2003·Arthritis and Rheumatism·Michelle PetriRobert A Brodsky
May 6, 2003·Lupus·E ToubiT D Golan
Jul 11, 2003·Immunology Letters·Pascal Schneider, Jürg Tschopp
Dec 13, 2003·Immunity·Gregory A VigliantiAnn Marshak-Rothstein
Dec 16, 2003·Arthritis and Rheumatism·William StohlDavid M Hilbert
Sep 24, 2004·Arthritis Research & Therapy·Meera Ramanujam, Anne Davidson
Jul 15, 2005·Annals of the New York Academy of Sciences·Jacques-Olivier PersPierre Youinou
Citations
May 31, 2008·Archivum Immunologiae Et Therapiae Experimentalis·Laura S TremlMichael P Cancro
Aug 8, 2008·Zeitschrift für Rheumatologie·E Aberer
Apr 27, 2011·Proceedings of the National Academy of Sciences of the United States of America·Canhui Guo, George R Stark
Jul 16, 2010·Journal of Virology·Alexander V GasparianAnton A Komar
Jul 13, 2011·Arthritis Research & Therapy·Pierre Youinou, Jacques-Olivier Pers
Jan 10, 2013·PloS One·Jianmin WangQi Jin
Dec 10, 2013·Journal of Dermatological Science·Benjamin F ChongGregory A Hosler
Aug 27, 2010·Journal of the American Academy of Dermatology·Annegret KuhnGisela Bonsmann
Nov 1, 2007·Dermatologic Therapy·Sunil Kalia, Jan P Dutz
Dec 1, 2011·Arthritis and Rheumatism·Chaim O JacobWilliam Stohl
Jan 23, 2015·Journal of Pineal Research·Pablo Medrano-CampilloAntonio Carrillo-Vico
Nov 26, 2014·Nature Reviews. Nephrology·Tak Mao Chan
Feb 16, 2011·Autoimmunity Reviews·Yoav ArnsonYehuda Shoenfeld
Nov 15, 2007·Clinical Pharmacology and Therapeutics·G R Mount, W R Gilliland
Mar 23, 2017·Blood·Subhradip MukhopadhyayRajabrata Sarkar
Oct 20, 2011·Nature Reviews. Nephrology·Senq-J LeeJoanne M Bargman
Jul 18, 2012·Nature Reviews. Rheumatology·Daniel J WallaceSwamy R Venuturupalli
Aug 22, 2009·Clinical Chemistry·Laëtitia Le PottierCapucine Daridon
Jul 23, 2016·Oncotarget·Alexander A ChumanevichLorne J Hofseth
Jul 8, 2020·Experimental Dermatology·Tanja Fetter, Joerg Wenzel
Nov 14, 2008·Autoimmunity·Zeping ZhouRenchi Yang
Oct 9, 2020·Journal of Experimental & Clinical Cancer Research : CR·Faiqa MudassarEric Hau
Sep 29, 2019·Seminars in Cancer Biology·Derek B OienViji Shridhar
Dec 18, 2020·Autoimmunity Reviews·Tamara MöckelAndreas Schwarting
Mar 8, 2021·Stem Cell Research·Alice Maria Giani, Shuibing Chen
Jan 28, 2021·Rheumatology·Julius LindblomIoannis Parodis