The regenerative role of adipose-derived stem cells (ADSC) in plastic and reconstructive surgery.

International Wound Journal
Naghmeh NaderiIain S Whitaker

Abstract

The potential use of stem cell-based therapies for the repair and regeneration of various tissues and organs offers a paradigm shift in plastic and reconstructive surgery. The use of either embryonic stem cells (ESC) or induced pluripotent stem cells (iPSC) in clinical situations is limited because of regulations and ethical considerations even though these cells are theoretically highly beneficial. Adult mesenchymal stem cells appear to be an ideal stem cell population for practical regenerative medicine. Among these cells, adipose-derived stem cells (ADSC) have the potential to differentiate the mesenchymal, ectodermal and endodermal lineages and are easy to harvest. Additionally, adipose tissue yields a high number of ADSC per volume of tissue. Based on this background knowledge, the purpose of this review is to summarise and describe the proliferation and differentiation capacities of ADSC together with current preclinical data regarding the use of ADSC as regenerative tools in plastic and reconstructive surgery.

References

Jan 1, 1989·Connective Tissue Research·R N RosierJ E Puzas
Dec 1, 1982·Mechanisms of Ageing and Development·E Schultz, B H Lipton
Feb 26, 2000·Clinical Cornerstone·L S Simon
Aug 11, 2000·Archives of Facial Plastic Surgery·D WatsonG P Lask
Dec 29, 2000·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·Y C HalvorsenJ M Gimble
Sep 27, 2001·Journal of Cellular Physiology·S GronthosJ M Gimble
Jan 31, 2002·Plastic and Reconstructive Surgery·Mark T BoschertMatthew J Concannon
Dec 12, 2002·Molecular Biology of the Cell·Patricia A ZukMarc H Hedrick
Mar 21, 2003·The Annals of Thoracic Surgery·Sunil RangappaEugene Kwang Sim Wei
Apr 30, 2003·Proceedings of the National Academy of Sciences of the United States of America·Masako MiuraSongtao Shi
Jul 2, 2003·Cells, Tissues, Organs·Daniel A De UgarteMarc H Hedrick
Jul 5, 2003·Physiological Reviews·Sabine Werner, Richard Grose
Jul 9, 2004·Biochemical and Biophysical Research Communications·Nitaya IndrawattanaAhnond Bunyaratvej
Jul 17, 2004·Annual Review of Biomedical Engineering·Charles W Patrick
Dec 30, 2004·The Journal of Biological Chemistry·Takayuki FurumatsuHiroshi Asahara
Mar 1, 2005·Biochimie·A-M RodriguezC Dani
Jul 20, 2005·Bulletin of Experimental Biology and Medicine·R A MusinaG T Sukhikh
Jan 18, 2006·Stem Cells·Kevin McIntoshJeffrey M Gimble
Feb 21, 2006·Trends in Biotechnology·John K FraserMarc H Hedrick
Aug 2, 2006·Proceedings of the National Academy of Sciences of the United States of America·Larissa V RodríguezLouis J Ignarro
Sep 16, 2006·Biomaterials·Cheryl T Gomillion, Karen J L Burg
Oct 27, 2006·Expert Review of Medical Devices·Karsten Hemmrich, Dennis von Heimburg
Nov 17, 2006·Cells, Tissues, Organs·Liu HongJoseph L Daw
May 15, 2007·Circulation Research·Jeffrey M GimbleBruce A Bunnell
May 15, 2007·Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft für Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft für Mikrochirurgie der Peripheren Nerven und Gefässe : Organ der Vereinigung der Deut·D F KalbermattenG Pierer
Aug 10, 2007·American Journal of Physiology. Cell Physiology·Xiaowen BaiEckhard Alt

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Citations

May 22, 2016·Clinical Reviews in Allergy & Immunology·Alexandre T J MariaPhilippe Guilpain
Jan 25, 2017·International Journal of Molecular Sciences·Meenakshi GaurVictoria V Lunyak
May 26, 2017·Plastic and Reconstructive Surgery·Chao LongPaige M Fox
Jul 25, 2018·Stem Cells and Development·Brice MagneMarina Trouillas
Nov 22, 2018·International Wound Journal·Oliver J SmithAsh Mosahebi
Apr 14, 2018·Tissue Engineering. Part B, Reviews·Molly N Pantelic, Lisa M Larkin
Oct 14, 2017·Aesthetic Surgery Journal·Jajini Varghese, Afshin Mosahebi
Mar 20, 2019·Stem Cells International·Claudio Luciano FranckJurandir Marcondes Ribas Filho
Nov 12, 2020·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·V Morgan JonesAdam J Katz
Feb 4, 2021·Journal of Plastic Surgery and Hand Surgery·Sheng-Hong LiHong-Wei Liu
Feb 4, 2021·Regenerative Medicine·Mohammed A BananiFarshid Sefat
Nov 22, 2019·Cryobiology·Haishui HuangO Berk Usta
Aug 8, 2021·Cells·Giuseppe GarroniMargherita Maioli
Aug 29, 2021·Pharmaceuticals·Deimantė NarauskaitėAistė Jekabsone

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