The region of the pontine parabrachial nucleus is a major target of dehydration-sensitive CRH neurons in the rat lateral hypothalamic area

The Journal of Comparative Neurology
A B Kelly, Alan G Watts

Abstract

Neurons in a restricted part of the lateral hypothalamic area (LHA) show increased expression of corticotropin-releasing hormone (CRH) mRNA as a consequence of cellular dehydration. In the present study, we have investigated the organization of their efferent projections by using anterograde and retrograde tracing techniques. Additionally, we have compared the distribution of CRH mRNA-containing neurons after cellular dehydration and intraventricular (i.c.v.) colchicine injections. Our results show that cellular dehydration activates a more restricted neuronal population than does i.c.v. colchicine. Iontophoretic injections of Phaseolus vulgaris leucoagglutinin (PHAL) were placed in the LHA of animals drinking hypertonic saline and their proximity to activated CRH neurons determined by in situ hybridization for CRH mRNA. Although labelled fibers from these injections were seen throughout the brain, the region of the parabrachial nucleus and nucleus of the solitary tract (NTS) were most conspicuous in also having CRH immunoreactive fibers. Injections of Fluoro-Gold placed in these two structures were used to confirm these findings in dehydrated animals. Significant numbers of neurons containing both Fluoro-Gold and CRH mRNA were...Continue Reading

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Citations

Apr 3, 2001·Annual Review of Neuroscience·A G Watts
Nov 6, 2007·Experimental Physiology·Joel C Geerling, Arthur D Loewy
Apr 20, 2010·Physiology & Behavior·Alan G Watts, Christina N Boyle
Oct 20, 2009·Frontiers in Neuroendocrinology·Alan G Watts, Casey M Donovan
Mar 19, 2011·Psychiatry and Clinical Neurosciences·Ken-ichi ShukunamiYuji Wada
May 19, 2012·The Journal of Comparative Neurology·Huxing CuiMichael Lutter
Mar 22, 2002·Frontiers in Neuroendocrinology·Harvey J Grill, Joel M Kaplan
Aug 31, 2000·Experimental Neurology·T C PritchardR Norgren
Jun 16, 2015·Frontiers in Systems Neuroscience·Joel D Hahn, Larry W Swanson
Mar 31, 2009·Neuroscience·K TokitaJ D Boughter
Apr 7, 2009·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Michael HelwigMartin Klingenspor
Apr 17, 2007·The Journal of Comparative Neurology·Alan G Watts, Graciela Sanchez-Watts
Dec 17, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Emilio De Castro e SilvaAlan Kim Johnson
Oct 20, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J P BairdJ B Travers
Apr 21, 2020·The Journal of Comparative Neurology·Silvia GaspariniJoel C Geerling
Dec 10, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Silvia GaspariniJoel C Geerling
Sep 7, 2021·Physiological Reviews·Alan G WattsWolfgang Langhans

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