The region responsible for stroke on chromosome 4 in the stroke-prone spontaneously hypertensive rat

Biochemical and Biophysical Research Communications
K IkedaY Yamori

Abstract

To detect genetic loci responsible for stroke susceptibility, we produced 107 male F2 progenies crossed between stroke-prone spontaneously hypertensive rats (SHRSP/Izm) and normotensive Wistar Kyoto rats (WKY/Izm) and followed them up until they developed cerebral stroke. One hundred and twenty-five simple sequence repeat (SSR) markers were analyzed in these F2 rats. Nine of 107 F2 rats suffered from macroscopically overt stroke. In these 9 rats, the segregation ratio of 3 genotypes at 6 SSR marker loci on chromosomes 2, 4, 9, and 10 was highly distorted from the expected value (the observed sp/sp:sp/wky:wky/ wky ratio was either 6:3:0 or 6:2:1, while the expected was 1:2:1, p < 0.01 by chi 2 test). Further, the brain weight was significantly heavier (p < 0.001) in the F2 rats suffering from stroke, suggesting that the brain weight was a parameter for stroke. The brain weight of F2 rats cosegregated with D4Mit19, D4Mgh7, and D4Mgh8 (p = 0.0015, 0.0014, and 0.0040 by ANOVA, respectively) on chromosome 4 supporting genetic effects of this genetic loci on the pathogenesis of cerebral stroke. Blood pressure did not cosegregate with these markers on chromosome 4. These results suggest that a region on chromosome 4, independently of ...Continue Reading

Citations

Jul 16, 1999·Clinical and Experimental Pharmacology & Physiology·Y Yamori
Jun 13, 2015·Molekuliarnaia biologiia·B V TitovO O Favorova
Jul 4, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S J ReadF C Barone
Jan 15, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·N KatoY Yamori
Dec 1, 2004·Stroke; a Journal of Cerebral Circulation·J K McGillI M Macrae
Jan 5, 2000·Physiological Reviews·J P Rapp

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