The regional cerebral blood flow changes in major depressive disorder with and without psychotic features

Progress in Neuro-psychopharmacology & Biological Psychiatry
Ali Saffet GonulAslan Oguz

Abstract

Depressive patients with psychotic features demonstrate distinct biological abnormalities in the hypothalamic-pituitary-adrenal axis (HPA), dopaminergic activity, electroencephalogram sleep profiles and measures of serotonergic function when compared to nonpsychotic depressive patients. However, very few functional neuroimaging studies were specifically designed for studying the effects of psychotic features on neuroimaging findings in depressed patients. The objective of the present study was to compare brain Single Photon Emission Tomography (SPECT) images in a group of unmedicated depressive patients with and without psychotic features. Twenty-eight patients who fully met DSM-IV criteria for major depressive disorder (MDD, 12 had psychotic features) were included in the study. They were compared with 16 control subjects matched for age, gender and education. Both psychotic and nonpsychotic depressed patients showed significantly lower regional cerebral blood flow (rCBF) values in the left and right superior frontal cortex, and left anterior cingulate cortex compared to those of controls. In comparison with depressive patients without psychotic features (DwoPF), depressive patients with psychotic features (DwPF) showed signif...Continue Reading

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Citations

Jul 14, 2011·Journal of Molecular Neuroscience : MN·Xin LiBaoxue Yang
Jul 3, 2013·Asian Journal of Psychiatry·Massimiliano BuoliAlfredo Carlo Altamura
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Oct 21, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ali Saffet GonulSimavi Vahip
Nov 20, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Wenbin GuoChangqing Xiao
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