PMID: 6168327Aug 10, 1981Paper

The regional distribution of somatostatin, substance P and neurotensin in human brain

Brain Research
P E CooperJ B Martin

Abstract

The regional distribution of somatostatin-, substance P- and neurotensin-like immunoreactivity was determined in 41 areas of 10 human brains. Each peptide is distributed widely in the human central nervous system and for each the pattern of distribution is unique. No significant relationship was found between peptide levels and patient age, interval between death and autopsy, and tissue storage time prior to assay. The regional distribution of these peptides is similar to that seen in several animal species and the pattern of this distribution is consistent with the idea that peptides function as neurotransmitters within the central nervous system. The problems of using human post-mortem material for peptide assay are discussed.

References

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Citations

Oct 1, 1996·Naunyn-Schmiedeberg's Archives of Pharmacology·V S ThossD Hoyer
Jul 1, 1987·Cell and Tissue Research·R JärviA Hervonen
Aug 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·A SchotteP M Laduron
Apr 1, 1985·Biulleten' eksperimental'noĭ biologii i meditsiny·E A IumatovR Ratsak
Jan 1, 1987·Journal of Neural Transmission·G SperkP Riederer
Jun 1, 1987·Neurochemical Pathology·M F BealJ B Martin
Dec 12, 1983·Brain Research·G W RobertsJ M Polak
May 7, 1984·Brain Research·M GoedertP C Emson
Jul 8, 1985·Brain Research·D M ArmstrongR D Terry
Jun 30, 1985·Clinica Chimica Acta; International Journal of Clinical Chemistry·Y C LeeS R Bloom
Jul 11, 1985·European Journal of Pharmacology·C A WhitfordC R Snell
Dec 1, 1983·Journal of the Neurological Sciences·I N FerrierG P McGregor
Oct 1, 1984·Journal of the Neurological Sciences·J A BigginsJ A Edwardson
Nov 1, 1985·Journal of the Neurological Sciences·M F BealJ B Martin
Oct 1, 1996·Journal of the Neurological Sciences·T MatsuishiH Kato
Nov 8, 1982·Life Sciences·P L WoodN P Nair

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