PMID: 9552409Jan 1, 1997Paper

The regulation of cyclin-dependent kinase inhibitors (CKIs)

Progress in Cell Cycle Research
M Peter

Abstract

Inhibitors of cyclin-dependent kinases (CKIs) play key roles in coordinating cell proliferation and development. They also function to control critical cell cycle transitions and as effectors of checkpoint pathways. The activity of CKIs is tightly controlled through the cell cycle and in response to various signals. Regulation generally affects the levels or availability of the CKIs rather than changing their intrinsic activities. Mechanisms controlling CKI function include the regulation of transcription, translation and proteolysis. In addition some signals appear to induce sequestration of CKIs within the cells, thereby changing their ability to interact with specific targets.

Citations

Dec 2, 2000·Cell Proliferation·K HelmbrechtL Rensing
Jun 3, 2000·Journal of Cardiovascular Pharmacology·D E AndréT F Lüscher
Jun 3, 2011·Mathematical Biosciences and Engineering : MBE·Orit LaviYoram Louzoun
Jan 8, 2017·Photochemistry and Photobiology·Mary K Montes de OcaFarrukh Afaq
Apr 27, 1999·The International Journal of Biochemistry & Cell Biology·O SavinovaR Jagus
Apr 9, 2011·Progress in Neurobiology·Joao P Lopes, Paula Agostinho

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