The regulation of glycogenolysis in the brain.

The Journal of Biological Chemistry
Owen W NadeauGerald M Carlson

Abstract

The key regulatory enzymes of glycogenolysis are phosphorylase kinase, a hetero-oligomer with four different types of subunits, and glycogen phosphorylase, a homodimer. Both enzymes are activated by phosphorylation and small ligands, and both enzymes have distinct isoforms that are predominantly expressed in muscle, liver, or brain; however, whole-transcriptome high-throughput sequencing analyses show that in brain both of these enzymes are likely composed of subunit isoforms representing all three tissues. This Minireview examines the regulatory properties of the isoforms of these two enzymes expressed in the three tissues, focusing on their potential regulatory similarities and differences. Additionally, the activity, structure, and regulation of the remaining enzyme necessary for glycogenolysis, glycogen-debranching enzyme, are also reviewed.

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Citations

Mar 9, 2018·The Journal of Biological Chemistry·Gerald M CarlsonRoger J Colbran
Mar 25, 2018·The Journal of Biological Chemistry·Lasse K BakHelle S Waagepetersen
Oct 31, 2018·Chemical Communications : Chem Comm·Federica Del GaudioMaria Chiara Monti
Feb 8, 2020·Brain Research·Kelly StarichaSusan Cohen
Jan 17, 2021·International Journal of Molecular Sciences·Karen P BriskiAyed A Alshamrani
Jun 3, 2021·International Journal of Molecular Sciences·Joana PoejoCarlos Gutierrez-Merino
Sep 18, 2021·Journal of Inherited Metabolic Disease·Chiara PizzamiglioRosaline Quinlivan
May 2, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ramachandran VinayagamBaojun Xu

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