Mar 13, 1987

The regulation of natural anticoagulant pathways

Science
C T Esmon

Abstract

Vascular endothelium plays an active role in preventing blood clot formation in vivo. One mechanism by which prevention is achieved involves a cell surface thrombin-binding protein, thrombomodulin, which converts thrombin into a protein C activator. Activated protein C then functions as an anticoagulant by inactivating two regulatory proteins of the coagulation system, factors Va and VIIIa. The physiological relevance of the protein C anticoagulant pathway is demonstrated by the identification of homozygous protein C--deficient infants with severe thrombotic complications. Recent studies suggest that this pathway provides a link between inflammation and coagulation.

Mentioned in this Paper

Biochemical Pathway
Thrombin Receptor Activating Peptides
Hormone Receptors, Cell Surface
Protein C, human
F2 gene
Papio
Thrombin
Protein C Measurement
THBD
Protein C Antigen Measurement

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