PMID: 8589505Aug 1, 1995Paper

The regulation of oxytocin receptor expression in human myometrial monolayer culture

Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi
S Adachi, M Oku

Abstract

Clarification of the mechanism of oxytocin (OT)-induced contraction of the uterus seems to be essential for the elucidation of the mechanism of the initiation of labor. Although it has been suggested that estradiol (E) and progesterone (P) are involved in the expression of oxytocin receptors (OTRs), no consensus opinion has been formed on this topic. Thus we recently assessed the effects of E and P on OTR expression using cultures of human uterine cells and we examined the changes in the expressed OTRs following treatment of the cell with exogenous OT. The following results were obtained: 1. The total cellular concentration of OTRs as measured in the myometrial crude membrane fraction (total OTR concentration) showed an increase dependent on the E concentration and on the length of the incubation period in the presence of E. This increase following treatment with E (10(-7) M) was suppressed by simultaneous treatment with P in a concentration-dependent manner; being suppressed by 50% when the concentration of P was 2.7 x 10(-6) M (E/P ratio = 0.037). When 1 nM OT was added to the culture, the total OTR concentration did not change within the first 30 minutes of incubation, but decreased by about 70% twenty-four hours after addit...Continue Reading

Citations

Feb 28, 2003·Biology of Reproduction·Makoto EgawaHideharu Kanzaki
Aug 4, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·Tsuyoshi NakamotoHideharu Kanzaki
Jun 19, 2013·Indian Journal of Endocrinology and Metabolism·Sunil K KotaKirtikumar D Modi
Apr 7, 2009·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Ragner LiedmanMats Akerlund
Jul 7, 2007·Seminars in Cell & Developmental Biology·Sam Mesiano, Toni N Welsh
Mar 11, 2004·BJOG : an International Journal of Obstetrics and Gynaecology·Etty Daniel-SpiegelEliezer Shalev
Jun 2, 2015·Frontiers in Physiology·Yujing J HengHarry M Georgiou
Feb 20, 2003·American Journal of Obstetrics and Gynecology·Christopher RobinsonRoger C Young
Oct 21, 2016·American Journal of Obstetrics and Gynecology·Jonathan W PaulRoger Smith
Jun 1, 2000·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J GutkowskaS M McCann
Oct 5, 2010·Reproductive Sciences·Sam MesianoErrol R Norwitz
Oct 16, 1999·The Journal of Clinical Endocrinology and Metabolism·A ChakravortyR B Jaffe
Mar 19, 2011·Current Opinion in Anaesthesiology·Robert A DyerBrendan Carvalho

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