The regulation of protein synthesis in heart muscle under normal conditions and in the adriamycin-cardiomyopathy

Klinische Wochenschrift
J Zähringer

Abstract

The regulation of cardiac protein synthesis, in particular messenger-RNA (mRNA) and polyribosome metabolism, has been investigated in normal rat heart muscle and in the adriamycin-cardiomyopathy by using newly developed methods for the isolation, characterization and in-vitro translation of cardiac polyribosomes and mRNA. The obtained data allow the following conclusions: 1. Normal heart muscle has a high content of polyribosomes (865 micrograms/g) and of mRNA (20-60 micrograms/g), and thus a high rate of protein synthesis. 2. The level of cardiac polyribosomes and mRNA is strictly age-dependent and much higher in young animals (2-3 x). This corresponds to a higher cardiac protein synthesis rate in young animals with a growing heart muscle, and shows that the protein-synthetic reserves of heart muscle decrease sharply with age. 3. Withdrawal of food for 1-3 days results in a pronounced decrease (-50% to -70%) of cardiac polyribosomes and mRNA, demonstrating that the cardiac protein synthesis reacts very sensitively to conditions of starving. 4. The cardiac polyribosomes and mRNA are unevenly distributed in the myocyte. The bulk of these substances is present in the cardiac microsomes, and much less is found in nuclei, myofibril...Continue Reading

References

Jul 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·D L Kacian, J C Myers
Dec 9, 1977·Deutsche medizinische Wochenschrift·R Herrman
Jan 1, 1979·Annual Review of Biochemistry·J M Taylor
May 1, 1977·Journal of Molecular and Cellular Cardiology·M W SeraydarianM F Goodman
Jun 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·S J ChanD F Steiner
Jan 1, 1976·Annual Review of Biochemistry·R P Perry
Sep 1, 1976·Cancer Treatment Reviews·L Lenaz, J A Page
Aug 1, 1976·European Journal of Biochemistry·H R Pelham, R J Jackson
Feb 1, 1977·The American Journal of Medicine·D D Von HoffF M Muggia
Jan 20, 1977·Biochimica Et Biophysica Acta·J ZähringerH N Munro
Aug 18, 1976·Biochimica Et Biophysica Acta·B S BaligaH N Munro
Mar 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·J ZähringerH N Munro
Apr 30, 1975·Molecular and Cellular Biochemistry·A R MeansB W O'Malley
Nov 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·L Clarke, J Carbon
Jul 22, 1975·Biochemical and Biophysical Research Communications·J ZähringerH N Munro
Apr 2, 1976·Biochimica Et Biophysica Acta·A J OuelletteR A Malt
Feb 23, 1976·Biochemical and Biophysical Research Communications·J ZähringerH N Munro
Jan 1, 1974·Basic Life Sciences·I M VermanD Baltimore
Jun 4, 1974·Biochemical and Biophysical Research Communications·Y IwamotoK Folkers
Jun 23, 1973·Biochimica Et Biophysica Acta·N Narayanan, J Eapen
Apr 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·S M HeywoodA Rich
Jun 1, 1973·Journal of Molecular and Cellular Cardiology·B I PosnerE L Fallen
Oct 1, 1973·Cancer·L M BujaE S Henderson
Feb 9, 1972·Nature: New Biology·I M VermaD Baltimore
Feb 9, 1972·Nature: New Biology·A BankP A Marks
Aug 1, 1973·Cancer·E A LefrakJ A Gottlieb
Sep 1, 1974·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M GosalvezB Chance
Jun 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·H Aviv, P Leder
Apr 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·R H Stevens, A R Williamson
Mar 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·A Przybyla, R C Strohman
Aug 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·B E Roberts, B M Paterson
Nov 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·G S McKnight, R T Schimke

❮ Previous
Next ❯

Citations

Mar 1, 1983·Basic Research in Cardiology·J ZähringerN Pritzl
Jul 29, 1999·Journal of Molecular and Cellular Cardiology·R J BoucekD A Dodd
Jan 1, 1987·Neuropathology and Applied Neurobiology·J B CavanaghP M Munro
Jan 1, 1985·Basic Research in Cardiology·J ZähringerG Stäb
Aug 15, 1989·Archives of Biochemistry and Biophysics·C H CampbellM C Linder

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.