PMID: 8041May 15, 1976

The regulation of rat liver tryptophan pyrrolase activity by reduced nicotinamide-adenine dinucleotide (phosphate). Experiments with glucose and nicotinamide

The Biochemical Journal
A A Badawy, M Evans

Abstract

1. Chronic administration of glucose or nicotinamide in drinking water inhibits the activity of rat liver tryptophan pyrrolase, and subsequent withdrawal causes an enhancement. The enzyme activity is also inhibited by administration in drinking water of sucrose, but not fructose, which is capable of preventing the glucose effect. 2. The inhibition by glucose or nictinamide is not due to a defective apoenzyme synthesis nor a decreased cofactor availability. 3. The inhibition by nicotinamide is reversed by regeneration of liver NAD+ and NADP+ in vivo by administration of fructose, pyruvate or phenazine methosulphate. Inhibition by glucose is also reversed by the above agents and by NH4Cl. Reversal of inhibition by glucose or nicotinamide is also achieved in vitro by addition of NAD+ or NADP+. 4. Glucose or nicotinamide increases liver [NADPH]. [NADP+] is also increased by nicotinamide. [NADPH] is also increased by sucrose, but not by fructose, which prevents the glucose effect. Phenazine methosulphate prevents the increase in [NADPH] caused by both glucose and nicotinamide. 5. It is suggested that the inhibition of tryptophan pyrrolase activity by glucose or nicotinamide is mediated by both NADPH and NADH.

Citations

Mar 11, 2008·Neurochemistry International·Christine L MillerSerge Weis
Feb 10, 2009·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·A A BadawyAlex Steptoe
Mar 15, 2014·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·A A Badawy
Jan 15, 2015·Journal of Psychopharmacology·A A Badawy, Donald M Dougherty
Jun 1, 2002·Nutrition Research Reviews·A A Badawy
Aug 2, 2013·Journal of Psychopharmacology·A A Badawy
Jun 20, 2008·Journal of Psychopharmacology·Sandra BarryT G Dinan
May 5, 2017·International Journal of Tryptophan Research : IJTR·A A Badawy
May 20, 2015·International Journal of Tryptophan Research : IJTR·Katsumi ShibataTsutomu Fukuwatari
Jun 12, 2018·Immunology and Cell Biology·A A Badawy
Mar 9, 2000·Diabetes/metabolism Research and Reviews·G WahlbergJ Svensson
Feb 1, 1987·The Proceedings of the Nutrition Society·T F SlaterW Xin
May 21, 2019·Egyptian Journal of Basic and Clinical Pharmacology·A A Badawy
Nov 11, 2019·Experimental Gerontology·A A Badawy

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