PMID: 375028Mar 20, 1979Paper

The regulation of RNA synthesis in yeast IV. Synthesis of double-stranded RNA

Molecular & General Genetics : MGG
J J Clare, S G Oliver

Abstract

A study has been made of the regulation of the synthesis of Pl double-stranded (ds) RNA, the genome of the yeast virus-like particle. When yeast protein synthesis is prevented by starvation for a required amino acid or by addition of cycloheximide, the rate of Pl dsRNA synthesis is reduced markedly. During nitrogen starvation the synthesis of Pl dsRNA persists but is accompanied by the degradation of pre-existing molecules. This degradation appears to require the induction of new enzymes and it is likely that the breakdown products are used to enable the cell to complete its division cycle. However, all of the copies of the VLP genome are not degraded in this process, some are conserved and can replenish the amount of Pl dsRNA on return to growth conditions. The controls which must operate on Pl dsRNA synthesis are discussed and compared with those exerted on nuclear RNA synthesis in yeast.

References

Mar 1, 1977·Experimental Cell Research·G C JohnstonL H Hartwell
Jun 1, 1977·Journal of Bacteriology·S G OliverB S Cox
Jul 20, 1977·Molecular & General Genetics : MGG·S G Oliver, C S McLaughlin
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May 1, 1969·Journal of Bacteriology·C T Wehr, L W Parks

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Citations

Jan 1, 1982·Molecular & General Genetics : MGG·J J Clare, S G Oliver
Dec 15, 1983·European Journal of Biochemistry·D J Mead, S G Oliver
Dec 3, 2005·Journal of Bacteriology·Toshiyuki UekiSumiko Inouye
Jul 1, 1980·Journal of Bacteriology·K A BostianD J Tipper
Jun 1, 1984·Microbiological Reviews·D J Tipper, K A Bostian

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