PMID: 629Nov 21, 1975

The regulation of striatal tyrosine hydroxylase. Effects of gamma hydroxybutric acid and healperidol

Naunyn-Schmiedeberg's Archives of Pharmacology
B ZivkovicE Costa

Abstract

Gamma-hydroxybutyric acid (GHBA) in doses that increased the striatal dopamine (DA) content of rat brain failed to increase the affinity of striatal tyrosine hydroxylase (TH) for its pterdine cofactor or to change the sensitivity of the enzyme to the inhibition by DA. Haloperidol (1 mg/kg) decreased the apparent Km of striatal TH for the pteridine cofactor. However, when GHBA was injected before haloperidol it prevented the decrease in the apparent Kn of TH, in a dose related manner. In vitro GHBA (10(-4) M) neither changed the stimulation of the striatal adenylyl cyclase by DA nor its inhibition by haloperidol. These results suggest that in striatal dopaminergic terminals the Kn of TH for the pteridine cofactor is regulated by an molecuular mechanism which requires that the impulse flow in the DA neurons is unimpaired.

References

Jan 1, 1972·Naunyn-Schmiedeberg's Archives of Pharmacology·P BédardM Lindqvist
Aug 24, 1973·Naunyn-Schmiedeberg's Archives of Pharmacology·N E Andén, G Stock
Aug 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·J W KebabianP Greengard
Mar 15, 1972·Experientia·N E AndénU Ungerstedt

Related Concepts

Adenylate Cyclase
Metazoa
Lentiform Nucleus Structure
Intropin
Haldol
Hydroxybutyric Acids
Synaptic Transmission
Protein KINASE
Pteridinones
Sensory Receptor Cells

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