The Regulatory Effects of Paeoniflorin and Its Derivative Paeoniflorin-6'-O-Benzene Sulfonate CP-25 on Inflammation and Immune Diseases

Frontiers in Pharmacology
Jiajie TuWei Wei

Abstract

The plant extract "total glucosides of peony" (TGP) constitutes a mixture of glycosides that is isolated from the roots of the well-known traditional Chinese herb Paeonia lactiflora Pall. Paeoniflorin (Pae) is the most abundant component and the main biologically active ingredient of TGP. Pharmacologically, Pae exhibits powerful anti-inflammatory and immune regulatory effects in some animal models of autoimmune diseases including Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE). Recently, we modified Pae with an addition of benzene sulfonate to achieve better bioavailability and higher anti-inflammatory immune regulatory effects. This review summarizes the pharmacological activities of Pae and the novel anti-inflammatory and immunomodulatory agent Paeoniflorin-6'-O-benzenesulfonate (CP-25) in various chronic inflammatory and autoimmune disorders. The regulatory effects of Pae and CP-25 make them promising agents for other related diseases, which require extensive investigation in the future.

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Citations

Apr 22, 2020·Immunopharmacology and Immunotoxicology·Weihua LiZhigang Wang
May 16, 2020·Frontiers in Pharmacology·Xiao MaYanling Zhao
May 19, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Xuan XiaQingchun Huang
Nov 27, 2020·Food & Nutrition Research·Yonghua ZhangBo Chen
Jan 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Young Sook KimDong Seon Kim
Jan 24, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Eric Aian P SilvaMárcio R V Santos
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lujain AloumGeorg A Petroianu

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Methods Mentioned

BETA
acetylation

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