The regulatory role of DNA supercoiling in nucleoprotein complex assembly and genetic activity

Biophysics Reviews
Georgi Muskhelishvili, Andrew Travers

Abstract

We argue that dynamic changes in DNA supercoiling in vivo determine both how DNA is packaged and how it is accessed for transcription and for other manipulations such as recombination. In both bacteria and eukaryotes, the principal generators of DNA superhelicity are DNA translocases, supplemented in bacteria by DNA gyrase. By generating gradients of superhelicity upstream and downstream of their site of activity, translocases enable the differential binding of proteins which preferentially interact with respectively more untwisted or more writhed DNA. Such preferences enable, in principle, the sequential binding of different classes of protein and so constitute an essential driver of chromatin organization.

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Citations

Mar 15, 2018·Nucleic Acids Research·Yan YanLaura Finzi
May 17, 2017·Biophysics Reviews·Cris Dos Remedios
Mar 20, 2019·Nature Reviews. Genetics·Paul B TalbertSteven Henikoff
Sep 14, 2018·Frontiers in Microbiology·Thøger J KroghChristoph Kaleta
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Dec 1, 2017·Current Genetics·Sam MeyerGeorgi Muskhelishvili
Jul 1, 2020·International Journal of Molecular Sciences·Syed Moiz Ahmed, Peter Dröge
Nov 4, 2020·Scientific Reports·Johanna Hörberg, Anna Reymer
Apr 30, 2021·The Journal of Physical Chemistry. B·Alena Klindziuk, Anatoly B Kolomeisky
Feb 8, 2018·Biochemistry·Semiha Kevser BaliViktorya Aviyente
Sep 7, 2021·Transcription·Megan Bergkessel

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