The regulatory roles of ROCK and MRCK kinases in the plasticity of cancer cell migration

Cancer Letters
Vijay Pralhad KaleJong K Yun

Abstract

Metastatic cancer cells show great plasticity in their migratory mechanisms. In this review we briefly describe the signal transduction pathways associated with the ROCK and MRCK kinases and their roles in cancer cell migration and in its plasticity. With respect to therapeutic strategies targeting metastatic cancers, selectively blocking a single target, such as ROCK or MRCK, can induce alternate modes of cancer cell migration (i.e. plasticity) making the treatment ineffective. To address the problem of plasticity, we will discuss the strategy of simultaneous targeting of both ROCK and MRCK as an effective anti-metastatic therapeutics.

References

Feb 9, 1996·Cell·D A Lauffenburger, A F Horwitz
Jun 1, 1996·The Journal of Cell Biology·M Chrzanowska-Wodnicka, K Burridge
Aug 23, 1996·The Journal of Biological Chemistry·M AmanoK Kaibuchi
Feb 1, 1997·Current Opinion in Cell Biology·N Tapon, A Hall
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Aug 18, 2000·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·N NakamuraK Kaibuchi
Feb 7, 2001·Journal of the National Cancer Institute·M Hidalgo, S G Eckhardt
Apr 6, 2001·The American Journal of Pathology·A K SoodM J Hendrix
Mar 30, 2002·Science·Lisa M CoussensLynn M Matrisian
May 29, 2002·Pathology International·Kazuki NabeshimaTetsuro Sameshima
Aug 22, 2002·Nature Reviews. Cancer·Jean Paul Thiery
Jan 30, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Avril V SomlyoAndrew P Somlyo
Jun 5, 2003·Nature Reviews. Molecular Cell Biology·Kirsi Riento, Anne J Ridley
Aug 2, 2003·Cancer Cell·Emmanuel VialChristopher J Marshall
Dec 6, 2003·Science·Anne J RidleyAlan Rick Horwitz
Jan 23, 2004·Nature Reviews. Cancer·John Condeelis, Jeffrey E Segall
Jun 8, 2004·Current Cancer Drug Targets·JianYu Rao, Ning Li
Jul 23, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Takao KamaiKen-Ichiro Yoshida
Jan 22, 2005·Current Opinion in Genetics & Development·Erik Sahai
Feb 22, 2005·Nature Cell Biology·Simon WilkinsonChristopher J Marshall
May 4, 2005·Molecular Cell·Takanori OtomoMichael K Rosen
Jun 16, 2005·Current Opinion in Pharmacology·Paul Elvin, Andrew P Garner
Jul 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Muhammad H ZamanPaul Matsudaira
Aug 8, 2006·Nature Medicine·Patricia S Steeg
Nov 18, 2006·Cell·Gaorav P Gupta, Joan Massagué

❮ Previous
Next ❯

Citations

Jan 5, 2016·Archivum Immunologiae Et Therapiae Experimentalis·Lei WeiJianjian Shi
Apr 23, 2016·Future Medicinal Chemistry·Samuel A McKie
Apr 12, 2019·Clinical & Experimental Metastasis·Johannes A Eble, Stephan Niland
Aug 30, 2017·International Journal of Oncology·G A CardamaD E Gomez
Apr 21, 2020·Frontiers in Cell and Developmental Biology·Natasha S Clayton, Anne J Ridley
May 13, 2020·Cancers·Haiyoung JungHee Gu Lee
Jan 30, 2020·International Journal of Molecular Sciences·Antonio Villalobo, Martin W Berchtold
Feb 1, 2018·Cancer Research·Mathieu UnbekandtMichael F Olson
May 3, 2019·IScience·Stephanie L CelanoJeffrey P MacKeigan
Jan 21, 2021·Cancer Metastasis Reviews·Carmen Ruggiero, Enzo Lalli
Jul 30, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Graziella Ribeiro de SousaMaría Sol Brassesco
Apr 22, 2021·Journal of Biomechanics·Anya B RobertsGiuliano Scarcelli

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Barrett Esophagus

Barrett’s esophagus if a serious complication of gastroesophageal reflux disease during which the normal esophageal lining changes to tissue that resembles intestinal lining. Here is the latest research.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Related Papers

The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry
André SchmandkeStephen M Strittmatter
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Tatiana Y PrudnikovaJonathan Chernoff
© 2021 Meta ULC. All rights reserved