The Reinforcing and Rewarding Effects of Methylone, a Synthetic Cathinone Commonly Found in "Bath Salts"

Journal of Addiction Research & Therapy
Lucas R WattersonM Foster Olive

Abstract

Methylone is a member of the designer drug class known as synthetic cathinones which have become increasingly popular drugs of abuse in recent years. Commonly referred to as "bath salts", these amphetamine-like compounds are sold as "legal" alternatives to illicit drugs such as cocaine, methamphetamine, and 3,4-methylenedioxymethamphetamine (MDMA, ecstasy). Following their dramatic rise in popularity along with numerous reports of toxicity and death, several of these drugs were classified as Schedule I drugs in the United States in 2012. Despite these bans, these drugs and other new structurally similar analogues continue to be abused. Currently, however, it is unknown whether these compounds possess the potential for compulsive use and addiction. The present study sought to determine the relative abuse liability of methylone by employing intravenous self-administration (IVSA) and intracranial self-stimulation (ICSS) paradigms in rats. We demonstrate that methylone (0.05, 0.1, 0.2, and 0.5 mg/kg/infusion) dose-dependently functions as a reinforcer, and that there is a significant positive relationship between methylone dose and reinforcer efficacy. Furthermore, responding during short access sessions (ShA, 2 hr/day) appeared mo...Continue Reading

Citations

Oct 21, 2014·Advances in Neuroscience·Lucas R Watterson, M Foster Olive
Sep 29, 2015·Current Addiction Reports·Brenda M GannonWilliam E Fantegrossi
Dec 10, 2013·Archives of Toxicology·Maria João ValenteMárcia Carvalho
Feb 25, 2015·Drug and Alcohol Dependence·Jennifer E NaylorSally L Huskinson
Jun 22, 2014·Clinical Schizophrenia & Related Psychoses·Michelle E JohnDavid Hahn
Dec 6, 2017·Frontiers in Psychiatry·Kristýna ŠtefkováTomáš Páleníček
Sep 8, 2017·Frontiers in Psychiatry·Aviv M WeinsteinEdythe D London
Jul 6, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Brenda M GannonGregory T Collins
Aug 15, 2020·Frontiers in Psychiatry·Benoit SchreckCaroline Victorri-Vigneau
Apr 1, 2021·The Journal of Pharmacology and Experimental Therapeutics·Nicole CentazzoMarta Concheiro
Jun 9, 2021·Archives of Toxicology·Jorge SoaresJoão Paulo Capela

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