The reinforcing, self-reported performance and physiological effects of Delta9-tetrahydrocannabinol, triazolam, hydromorphone, and methylphenidate in cannabis users.

Behavioural Pharmacology
Joshua A LileLon R Hays

Abstract

The use of illicit prescription drugs is common in cannabis users; however, the effects of few psychoactive drugs have been characterized in this population. In this study, Delta-tetrahydrocannabinol (i.e. Delta-THC), triazolam, hydromorphone, and methylphenidate were administered to cannabis users (n=8). Subjects completed the multiple-choice procedure to assess drug reinforcement, as well as self-report questionnaires and performance tasks; physiological assessments were also conducted. Only Delta-THC increased the crossover point on the multiple-choice procedure, but all of the drugs increased ratings on one or more 'positive' drug-effect questionnaire items, as well as items specific for each drug. Triazolam produced the most robust performance impairment, except on a time reproduction task, which was impacted to a greater degree by Delta-THC. Delta-THC elevated heart rate and decreased temperature, triazolam increased heart rate, methylphenidate elevated all cardiovascular indices, and hydromorphone reduced respiration. The effects of the drugs tested in this study were generally consistent with their known pharmacology, although minimal responses to hydromorphone were observed. Future research to directly compare the effe...Continue Reading

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Citations

Feb 9, 2011·Behavioural Pharmacology·Stephanie C LicataScott E Lukas
Sep 17, 2013·Expert Opinion on Investigational Drugs·Christopher D VerricoRichard De La Garza
Jan 19, 2016·Pharmacology, Biochemistry, and Behavior·Jessica S FogelJoshua A Lile
May 10, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Corinde E WiersNora D Volkow
Jun 12, 2013·Journal of Clinical Pharmacology·Joshua A LileLon R Hays
May 11, 2011·IUBMB Life·Gabriella FanaliMauro Fasano
Oct 9, 2012·Peptides·Richard J Bodnar

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